Erythrocytes as Carriers: From Drug Delivery to Biosensors

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from the carrier; as bioreactors with encapsulated enzymes performing the necessary reactions,...

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Bibliographic Details
Published in:Pharmaceutics 2020-03, Vol.12 (3), p.276
Main Authors: Koleva, Larisa, Bovt, Elizaveta, Ataullakhanov, Fazoil, Sinauridze, Elena
Format: Article
Language:English
Subjects:
Biosensors
Blood
carrier erythrocyte
diagnostics
Disease
drug delivery
Enzymes
erythrocyte
erythrocyte-bioreactor
Erythrocytes
Hemodialysis
Review
targeted drug delivery
therapy
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Summary:Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from the carrier; as bioreactors with encapsulated enzymes performing the necessary reactions, while remaining inaccessible to the immune system and plasma proteases; or as a tool for targeted drug delivery to target organs, primarily to cells of the reticuloendothelial system, liver and spleen. To date, erythrocytes have been studied as carriers for a wide range of drugs, such as enzymes, antibiotics, anti-inflammatory, antiviral drugs, etc., and for diagnostic purposes (e.g. magnetic resonance imaging). The review focuses only on drugs loaded inside erythrocytes, defines the main lines of research for erythrocytes with bioactive substances, as well as the advantages and limitations of their application. Particular attention is paid to in vivo studies, opening-up the potential for the clinical use of drugs encapsulated into erythrocytes.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics12030276