Peptaibol Analogs Show Potent Antibacterial Activity against Multidrug Resistant Opportunistic Pathogens

New classes of antibacterial drugs are urgently needed to address the global issue of antibiotic resistance. In this context, peptaibols are promising membrane-active peptides since they are not involved in innate immunity and their antimicrobial activity does not involve specific cellular targets,...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (9), p.7997
Main Authors: Dalla Torre, Chiara, Sannio, Filomena, Battistella, Mattia, Docquier, Jean-Denis, De Zotti, Marta
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Aib
Analogs
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial activity
Antibacterial agents
Antibiotic resistance
Antibiotics
Antimicrobial activity
Antimicrobial agents
Antimicrobial Cationic Peptides - pharmacology
Bacteria
Bacterial infections
Chromatography
Clinical isolates
Drug resistance
Drug Resistance, Multiple, Bacterial
Enzymes
Gram-negative bacteria
Gram-positive bacteria
helical conformation
Innate immunity
Methicillin
Microbial Sensitivity Tests
Multidrug resistance
Multidrug resistant organisms
multidrug-resistant pathogens
Opportunist infection
Organisms
Pathogens
peptaibol
Peptaibols
Peptides
Pharmacology
Proteolysis
Pseudomonas aeruginosa
Staphylococcus aureus
Therapeutic applications
Trichogin
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Summary:New classes of antibacterial drugs are urgently needed to address the global issue of antibiotic resistance. In this context, peptaibols are promising membrane-active peptides since they are not involved in innate immunity and their antimicrobial activity does not involve specific cellular targets, therefore reducing the chance of bacterial resistance development. Trichogin GA IV is a nonhemolytic, natural, short-length peptaibol active against Gram-positive bacteria and resistant to proteolysis. In this work, we report on the antibacterial activity of cationic trichogin analogs. Several peptides appear non-hemolytic and strongly active against many clinically relevant bacterial species, including antibiotic-resistant clinical isolates, such as , , and extensively drug-resistant , against which there are only a limited number of antibiotics under development. Our results further highlight how the modification of natural peptides is a valuable strategy for obtaining improved antibacterial agents with potential therapeutic applications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24097997