Stimulation of Perforant Path Fibers Induces LTP Concurrently in Amygdala and Hippocampus in Awake Freely Behaving Rats

Long-term potentiation (LTP) which has long been considered a cellular model for learning and memory is defined as a lasting enhancement in synaptic transmission efficacy. This cellular mechanism has been demonstrated reliably in the hippocampus and the amygdala—two limbic structures implicated in l...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2013-01, Vol.2013 (2013), p.348-353
Main Authors: Blaise, J. Harry, Hartman, Rachel A.
Format: Article
Language:English
Subjects:
Amygdala (Brain)
Amygdala - physiology
Animals
Brain
Brain research
Electric Stimulation - methods
Experiments
Hippocampus (Brain)
Hippocampus - physiology
Laboratory animals
Long-Term Potentiation - physiology
Male
Neural transmission
Perforant Pathway - physiology
Physiological aspects
Population
Rats
Rats, Sprague-Dawley
Recording equipment
Statistical analysis
Studies
Wakefulness - physiology
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Summary:Long-term potentiation (LTP) which has long been considered a cellular model for learning and memory is defined as a lasting enhancement in synaptic transmission efficacy. This cellular mechanism has been demonstrated reliably in the hippocampus and the amygdala—two limbic structures implicated in learning and memory. Earlier studies reported on the ability of cortical stimulation of the entorhinal cortex to induce LTP simultaneously in the two sites. However, to retain a stable baseline of comparison with the majority of the LTP literature, it is important to investigate the ability of fiber stimulation such as perforant path activation to induce LTP concurrently in both structures. Therefore, in this paper we report on concurrent LTP in the basolateral amygdala (BLA) and the dentate gyrus (DG) subfield of the hippocampus induced by theta burst stimulation of perforant path fibers in freely behaving Sprague-Dawley rats. Our results indicate that while perforant path-evoked potentials in both sites exhibit similar triphasic waveforms, the latency and amplitude of BLA responses were significantly shorter and smaller than those of DG. In addition, we observed no significant differences in either the peak level or the duration of LTP between DG and BLA.
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2013/565167