Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese

Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with...

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Bibliographic Details
Published in:International journal of hypertension 2020, Vol.2020 (2020), p.1-7
Main Authors: Li, Ping, Niu, Wenquan, Cao, Yongtong, Liu, Qian, Yan, Meihua, Zhao, Tingting, Liu, Huijie, Yu, Meijie, Zhao, Hailing, Ma, Liang, Jiang, Yongwei
Format: Article
Language:English
Subjects:
Automation
Blood pressure
Body mass index
Cholesterol
Deoxyribonucleic acid
DNA
Enzymes
Gender
Genes
Genetic aspects
Genetic testing
Genotype & phenotype
Homocysteine
Hydrolases
Hypertension
Lipoproteins
Medical laboratories
Medical research
Medicine, Experimental
Mutagenesis
Regression analysis
Risk factors
Standard deviation
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Summary:Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with enzyme activity of soluble epoxide hydrolase. Methods. This study involved 782 patients with primary hypertension and 458 healthy controls. Genotyping was done using TaqMan technique. Activity of soluble epoxide hydrolase fusion proteins was evaluated by the conversion of 11,12-EET to corresponding 11,12-DHET using ELISA kit. Results. After taking carriers of R287Q variant GG genotype as a reference, those with GA genotype had a significantly reduced risk of hypertension (adjusted odds ratio: 0.72, 95% confidence interval: 0.56 to 0.93, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833, P
ISSN:2090-0384
2090-0392
2090-0392
DOI:10.1155/2020/2351547