Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese

Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hypertension 2020, Vol.2020 (2020), p.1-7
Main Authors: Li, Ping, Niu, Wenquan, Cao, Yongtong, Liu, Qian, Yan, Meihua, Zhao, Tingting, Liu, Huijie, Yu, Meijie, Zhao, Hailing, Ma, Liang, Jiang, Yongwei
Format: Article
Language:English
Subjects:
Automation
Blood pressure
Body mass index
Cholesterol
Deoxyribonucleic acid
DNA
Enzymes
Gender
Genes
Genetic aspects
Genetic testing
Genotype & phenotype
Homocysteine
Hydrolases
Hypertension
Lipoproteins
Medical laboratories
Medical research
Medicine, Experimental
Mutagenesis
Regression analysis
Risk factors
Standard deviation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3
cites cdi_FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3
container_end_page 7
container_issue 2020
container_start_page 1
container_title International journal of hypertension
container_volume 2020
creator Li, Ping
Niu, Wenquan
Cao, Yongtong
Liu, Qian
Yan, Meihua
Zhao, Tingting
Liu, Huijie
Yu, Meijie
Zhao, Hailing
Ma, Liang
Jiang, Yongwei
description Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with enzyme activity of soluble epoxide hydrolase. Methods. This study involved 782 patients with primary hypertension and 458 healthy controls. Genotyping was done using TaqMan technique. Activity of soluble epoxide hydrolase fusion proteins was evaluated by the conversion of 11,12-EET to corresponding 11,12-DHET using ELISA kit. Results. After taking carriers of R287Q variant GG genotype as a reference, those with GA genotype had a significantly reduced risk of hypertension (adjusted odds ratio: 0.72, 95% confidence interval: 0.56 to 0.93, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833, P
doi_str_mv 10.1155/2020/2351547
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_9a19e650a4914f46bc6944defd7096d0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A622271962</galeid><doaj_id>oai_doaj_org_article_9a19e650a4914f46bc6944defd7096d0</doaj_id><sourcerecordid>A622271962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3</originalsourceid><addsrcrecordid>eNqNkl1r2zAUhs3YWEvXu10PwWAMtrT6sCTrphBCmxYKG2O7FrJ9FCtzpExy1vXfV16ytBm7mGWQkZ7zWD5-i-I1wWeEcH5OMcXnlHHCS_msOKZY4Qlmij7fP1flUXGa0hLni6l8Vy-LI0ZJRTDBx0UzTSk0zgwueBQsulyHX64FdH3fxtCbBIiiOXhA07iglZz3Ht25oUNDB-iLS9-RDRF9jm5l4n0uWkMcwKdR5jyadc5DglfFC2v6BKe7-aT4dnX5dXY9uf00v5lNbyeNYHyYWKC1BQu1pRUXsq6xJVTWTaskV5SxllkhLQCTnEhMhKiUVWBrSgnFeYedFDdbbxvMUq-3h9LBOP17IcSFNnFwTQ9aGaJAcGxKRUpbiroRqixbsK3ESrQ4uy62rvWmXkHbgB-i6Q-khzvedXoRfmqJRVnxUfB-J4jhxwbSoFcuNdD3xkPYJE2ZlKrivBrRt3-hy7CJPrdqpPIfU4qWj9TC5A9w3ob83maU6qmglEqiBM3U2T-oPFpYuSZ4sC6vHxS8e1LQgemHLoV-MwYiHYIft2ATQ0oR7L4ZBOsxjHoMo96FMeNvnjZwD_-JXgY-bIEcktbcuf_UQWbAmkeayAxL9gC70exz</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2373989924</pqid></control><display><type>article</type><title>Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese</title><source>PubMed Central Free</source><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><creator>Li, Ping ; Niu, Wenquan ; Cao, Yongtong ; Liu, Qian ; Yan, Meihua ; Zhao, Tingting ; Liu, Huijie ; Yu, Meijie ; Zhao, Hailing ; Ma, Liang ; Jiang, Yongwei</creator><contributor>Ong, Kwok Leung ; Kwok Leung Ong</contributor><creatorcontrib>Li, Ping ; Niu, Wenquan ; Cao, Yongtong ; Liu, Qian ; Yan, Meihua ; Zhao, Tingting ; Liu, Huijie ; Yu, Meijie ; Zhao, Hailing ; Ma, Liang ; Jiang, Yongwei ; Ong, Kwok Leung ; Kwok Leung Ong</creatorcontrib><description>Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with enzyme activity of soluble epoxide hydrolase. Methods. This study involved 782 patients with primary hypertension and 458 healthy controls. Genotyping was done using TaqMan technique. Activity of soluble epoxide hydrolase fusion proteins was evaluated by the conversion of 11,12-EET to corresponding 11,12-DHET using ELISA kit. Results. After taking carriers of R287Q variant GG genotype as a reference, those with GA genotype had a significantly reduced risk of hypertension (adjusted odds ratio: 0.72, 95% confidence interval: 0.56 to 0.93, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833, P&lt;0.001). Enzyme activity of soluble epoxide hydrolase was significantly lower in the R287Q group than in the wild type group. Conclusions. We provide evidence that R287Q mutation in EPHX2 gene was associated with reduced risk of primary hypertension and low activity of soluble epoxide hydrolase.</description><identifier>ISSN: 2090-0384</identifier><identifier>ISSN: 2090-0392</identifier><identifier>EISSN: 2090-0392</identifier><identifier>DOI: 10.1155/2020/2351547</identifier><identifier>PMID: 32181010</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Automation ; Blood pressure ; Body mass index ; Cholesterol ; Deoxyribonucleic acid ; DNA ; Enzymes ; Gender ; Genes ; Genetic aspects ; Genetic testing ; Genotype &amp; phenotype ; Homocysteine ; Hydrolases ; Hypertension ; Lipoproteins ; Medical laboratories ; Medical research ; Medicine, Experimental ; Mutagenesis ; Regression analysis ; Risk factors ; Standard deviation</subject><ispartof>International journal of hypertension, 2020, Vol.2020 (2020), p.1-7</ispartof><rights>Copyright © 2020 Liang Ma et al.</rights><rights>COPYRIGHT 2020 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2020 Liang Ma et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Liang Ma et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3</citedby><cites>FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3</cites><orcidid>0000-0001-9425-0825 ; 0000-0003-3226-4150 ; 0000-0002-8904-3060 ; 0000-0002-3315-2276 ; 0000-0002-4974-0283 ; 0000-0003-1715-3372 ; 0000-0003-0533-909X ; 0000-0001-6380-2009 ; 0000-0002-3323-9507</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2373989924/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2373989924?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,25753,27923,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32181010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ong, Kwok Leung</contributor><contributor>Kwok Leung Ong</contributor><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Niu, Wenquan</creatorcontrib><creatorcontrib>Cao, Yongtong</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Yan, Meihua</creatorcontrib><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Liu, Huijie</creatorcontrib><creatorcontrib>Yu, Meijie</creatorcontrib><creatorcontrib>Zhao, Hailing</creatorcontrib><creatorcontrib>Ma, Liang</creatorcontrib><creatorcontrib>Jiang, Yongwei</creatorcontrib><title>Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese</title><title>International journal of hypertension</title><addtitle>Int J Hypertens</addtitle><description>Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with enzyme activity of soluble epoxide hydrolase. Methods. This study involved 782 patients with primary hypertension and 458 healthy controls. Genotyping was done using TaqMan technique. Activity of soluble epoxide hydrolase fusion proteins was evaluated by the conversion of 11,12-EET to corresponding 11,12-DHET using ELISA kit. Results. After taking carriers of R287Q variant GG genotype as a reference, those with GA genotype had a significantly reduced risk of hypertension (adjusted odds ratio: 0.72, 95% confidence interval: 0.56 to 0.93, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833, P&lt;0.001). Enzyme activity of soluble epoxide hydrolase was significantly lower in the R287Q group than in the wild type group. Conclusions. We provide evidence that R287Q mutation in EPHX2 gene was associated with reduced risk of primary hypertension and low activity of soluble epoxide hydrolase.</description><subject>Automation</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cholesterol</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Gender</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic testing</subject><subject>Genotype &amp; phenotype</subject><subject>Homocysteine</subject><subject>Hydrolases</subject><subject>Hypertension</subject><subject>Lipoproteins</subject><subject>Medical laboratories</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mutagenesis</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Standard deviation</subject><issn>2090-0384</issn><issn>2090-0392</issn><issn>2090-0392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAUhs3YWEvXu10PwWAMtrT6sCTrphBCmxYKG2O7FrJ9FCtzpExy1vXfV16ytBm7mGWQkZ7zWD5-i-I1wWeEcH5OMcXnlHHCS_msOKZY4Qlmij7fP1flUXGa0hLni6l8Vy-LI0ZJRTDBx0UzTSk0zgwueBQsulyHX64FdH3fxtCbBIiiOXhA07iglZz3Ht25oUNDB-iLS9-RDRF9jm5l4n0uWkMcwKdR5jyadc5DglfFC2v6BKe7-aT4dnX5dXY9uf00v5lNbyeNYHyYWKC1BQu1pRUXsq6xJVTWTaskV5SxllkhLQCTnEhMhKiUVWBrSgnFeYedFDdbbxvMUq-3h9LBOP17IcSFNnFwTQ9aGaJAcGxKRUpbiroRqixbsK3ESrQ4uy62rvWmXkHbgB-i6Q-khzvedXoRfmqJRVnxUfB-J4jhxwbSoFcuNdD3xkPYJE2ZlKrivBrRt3-hy7CJPrdqpPIfU4qWj9TC5A9w3ob83maU6qmglEqiBM3U2T-oPFpYuSZ4sC6vHxS8e1LQgemHLoV-MwYiHYIft2ATQ0oR7L4ZBOsxjHoMo96FMeNvnjZwD_-JXgY-bIEcktbcuf_UQWbAmkeayAxL9gC70exz</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Li, Ping</creator><creator>Niu, Wenquan</creator><creator>Cao, Yongtong</creator><creator>Liu, Qian</creator><creator>Yan, Meihua</creator><creator>Zhao, Tingting</creator><creator>Liu, Huijie</creator><creator>Yu, Meijie</creator><creator>Zhao, Hailing</creator><creator>Ma, Liang</creator><creator>Jiang, Yongwei</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9425-0825</orcidid><orcidid>https://orcid.org/0000-0003-3226-4150</orcidid><orcidid>https://orcid.org/0000-0002-8904-3060</orcidid><orcidid>https://orcid.org/0000-0002-3315-2276</orcidid><orcidid>https://orcid.org/0000-0002-4974-0283</orcidid><orcidid>https://orcid.org/0000-0003-1715-3372</orcidid><orcidid>https://orcid.org/0000-0003-0533-909X</orcidid><orcidid>https://orcid.org/0000-0001-6380-2009</orcidid><orcidid>https://orcid.org/0000-0002-3323-9507</orcidid></search><sort><creationdate>2020</creationdate><title>Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese</title><author>Li, Ping ; Niu, Wenquan ; Cao, Yongtong ; Liu, Qian ; Yan, Meihua ; Zhao, Tingting ; Liu, Huijie ; Yu, Meijie ; Zhao, Hailing ; Ma, Liang ; Jiang, Yongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Automation</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cholesterol</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Gender</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic testing</topic><topic>Genotype &amp; phenotype</topic><topic>Homocysteine</topic><topic>Hydrolases</topic><topic>Hypertension</topic><topic>Lipoproteins</topic><topic>Medical laboratories</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mutagenesis</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Standard deviation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Niu, Wenquan</creatorcontrib><creatorcontrib>Cao, Yongtong</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Yan, Meihua</creatorcontrib><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Liu, Huijie</creatorcontrib><creatorcontrib>Yu, Meijie</creatorcontrib><creatorcontrib>Zhao, Hailing</creatorcontrib><creatorcontrib>Ma, Liang</creatorcontrib><creatorcontrib>Jiang, Yongwei</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest_Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ping</au><au>Niu, Wenquan</au><au>Cao, Yongtong</au><au>Liu, Qian</au><au>Yan, Meihua</au><au>Zhao, Tingting</au><au>Liu, Huijie</au><au>Yu, Meijie</au><au>Zhao, Hailing</au><au>Ma, Liang</au><au>Jiang, Yongwei</au><au>Ong, Kwok Leung</au><au>Kwok Leung Ong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese</atitle><jtitle>International journal of hypertension</jtitle><addtitle>Int J Hypertens</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2090-0384</issn><issn>2090-0392</issn><eissn>2090-0392</eissn><abstract>Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives. We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene with primary hypertension risk and examine its association with enzyme activity of soluble epoxide hydrolase. Methods. This study involved 782 patients with primary hypertension and 458 healthy controls. Genotyping was done using TaqMan technique. Activity of soluble epoxide hydrolase fusion proteins was evaluated by the conversion of 11,12-EET to corresponding 11,12-DHET using ELISA kit. Results. After taking carriers of R287Q variant GG genotype as a reference, those with GA genotype had a significantly reduced risk of hypertension (adjusted odds ratio: 0.72, 95% confidence interval: 0.56 to 0.93, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833, P&lt;0.001). Enzyme activity of soluble epoxide hydrolase was significantly lower in the R287Q group than in the wild type group. Conclusions. We provide evidence that R287Q mutation in EPHX2 gene was associated with reduced risk of primary hypertension and low activity of soluble epoxide hydrolase.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32181010</pmid><doi>10.1155/2020/2351547</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9425-0825</orcidid><orcidid>https://orcid.org/0000-0003-3226-4150</orcidid><orcidid>https://orcid.org/0000-0002-8904-3060</orcidid><orcidid>https://orcid.org/0000-0002-3315-2276</orcidid><orcidid>https://orcid.org/0000-0002-4974-0283</orcidid><orcidid>https://orcid.org/0000-0003-1715-3372</orcidid><orcidid>https://orcid.org/0000-0003-0533-909X</orcidid><orcidid>https://orcid.org/0000-0001-6380-2009</orcidid><orcidid>https://orcid.org/0000-0002-3323-9507</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-0384
ispartof International journal of hypertension, 2020, Vol.2020 (2020), p.1-7
issn 2090-0384
2090-0392
2090-0392
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_9a19e650a4914f46bc6944defd7096d0
source PubMed Central Free; Wiley Online Library Open Access; Publicly Available Content Database
subjects Automation
Blood pressure
Body mass index
Cholesterol
Deoxyribonucleic acid
DNA
Enzymes
Gender
Genes
Genetic aspects
Genetic testing
Genotype & phenotype
Homocysteine
Hydrolases
Hypertension
Lipoproteins
Medical laboratories
Medical research
Medicine, Experimental
Mutagenesis
Regression analysis
Risk factors
Standard deviation
title Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T10%3A26%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Epoxide%20Hydrolase%202%20Gene%20Arg287Gln%20with%20the%20Risk%20for%20Primary%20Hypertension%20in%20Chinese&rft.jtitle=International%20journal%20of%20hypertension&rft.au=Li,%20Ping&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=2090-0384&rft.eissn=2090-0392&rft_id=info:doi/10.1155/2020/2351547&rft_dat=%3Cgale_doaj_%3EA622271962%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c635t-fe2bfefebf28567bb0f127bcd9759233d3f67fee37517016689f9efb2212067f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2373989924&rft_id=info:pmid/32181010&rft_galeid=A622271962&rfr_iscdi=true