TbpB-based oral mucosal vaccine provides heterologous protection against Glässer's disease caused by different serovars of Spanish field isolates of Glaesserella parasuis

Glaesserella parasuis (G. parasuis) is the primary agent of Glässer's disease, significantly affecting nursery and early fattening piglets. Current prophylactic measures, mainly serovar-specific bacterins administered to sows, are limited by maternal immunity, which can interfere with active im...

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Published in:Porcine Health Management. 2024-11, Vol.10 (1), p.57-16, Article 57
Main Authors: González-Fernández, Alba, Mencía-Ares, Oscar, García-Iglesias, María José, Petrocchi-Rilo, Máximo, Miguélez-Pérez, Rubén, Perelló-Jiménez, Alberto, Herencia-Lagunar, Elena, Acebes-Fernández, Vanessa, Gutiérrez-Martín, César B, Martínez-Martínez, Sonia
Format: Article
Language:English
Subjects:
Cross-protection
Glaesserella parasuis
Glässer’s disease
Humoral immune response
Immunization
Needle-free vaccination
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Summary:Glaesserella parasuis (G. parasuis) is the primary agent of Glässer's disease, significantly affecting nursery and early fattening piglets. Current prophylactic measures, mainly serovar-specific bacterins administered to sows, are limited by maternal immunity, which can interfere with active immunization in piglets. Subunit vaccines containing G. parasuis-specific antigenic molecules show promise but are not yet commercially available. Transferrin-binding proteins (Tbp), which enable G. parasuis to acquire iron in low-iron environments like mucosal surfaces, have been proposed as potential vaccine antigens. The mucosal administration of a TbpB-based subunit vaccine could provide a promising solution to overcome the limitations posed by maternal immunity, offering an effective approach to control the disease in weaning piglets. This study, conducted in two phases, primarily evaluates (days 0-45) the immunogenicity of a two-dose oral mucosal TbpB-based subunit vaccine (TbpB ) administered to colostrum-deprived piglets, and subsequently (days 45-52), its heterologous protection by challenging these piglets with four G. parasuis clinical isolates from different TbpB clusters (I, III) and serovars (SV1, SV4, SV5, SV7) recovered from Spanish pig farms. The oral mucosal administration of the two-dose TbpB-based vaccine induced a robust humoral immune response in immunized colostrum-deprived piglets, significantly increasing IgA and IgM concentration 15 days after the second dose (p 
ISSN:2055-5660
2055-5660
DOI:10.1186/s40813-024-00404-7