Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats

• Published in: Antioxidants 2022-02, Vol.11 (2), p.380
• Main Authors: Sip, Szymon, Szymanowska, Daria, Chanaj-Kaczmarek, Justyna, Skalicka-Woźniak, Krystyna, Budzyńska, Barbara, Wronikowska-Denysiuk, Olga, Słowik, Tymoteusz, Szulc, Piotr, Cielecka-Piontek, Judyta
• Format: Article
• Language: English
• Subjects: antioxidant activity; Antioxidants; Bacteria; Biological activity; Blood vessels; Carbohydrates; civilization disease; Cornus mas; Cultivars; Diabetes; Diabetes mellitus; Disease; disease prevention; Drug therapy; enzyme inhibition; Enzymes; freeze drying; Fruits; glucose; Inflammation; Insulin; Intestinal microflora; intestinal microorganisms; Inulin; Metabolic pathways; Metabolism; microbiome; Microbiota; Microorganisms; natural compounds; Oxidative stress; Plant extracts; Prebiotics; Prophylaxis; Streptozocin; streptozotocin; therapeutics; α-Glucosidase
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox11020380

As a systemic disease, diabetes mellitus (DM) is characterized by the disruption of many glucose metabolic pathways. Therefore, it seems critical to study new therapies to support treatment to develop therapeutic systems that can operate across a broad metabolic spectrum. The current state of knowledge indicates an essential role of the gut microbiota in the development and course of the disease. fruits have demonstrated a rich biological activity profile and potential for application in the treatment of DM. As part of a preliminary analysis, the activity of four cultivars of fruits was analyzed. The cultivar was selected as having the highest activity in in vitro conditions for further prebiotic system preparation. The study aimed to develop a unique therapeutic system based, first of all, on the mechanism of α-glucosidase inhibition and the antioxidant effect resulting from the activity of the plant extract used, combined with the prebiotic effect of inulin. The obtained system was characterized in vitro in terms of antioxidant activity and enzyme inhibition capacity, and was then tested on diabetic rats. The study was coupled with an analysis of changes in the intestinal microflora. The system of prebiotic stabilized L. lyophilized extract with inulin offers valuable support for the prophylaxis and treatment of DM.