The Potential Use of Honey as a Neuroprotective Agent for the Management of Neurodegenerative Diseases

As the global population ages, there is an increasing research on managing neurodegenerative diseases that mainly affect the elderly. Honey is one of the natural products and functional foods widely studied for its neuroprotective properties. This review investigates honey's effectiveness as a...

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Bibliographic Details
Published in:Nutrients 2023-03, Vol.15 (7), p.1558
Main Authors: Fadzil, Mohammad Adi Mohammad, Mustar, Suraiami, Rashed, Aswir Abd
Format: Article
Language:English
Subjects:
Aged
Alzheimer's disease
antioxidant
Antioxidants - therapeutic use
Degeneration
Disease management
Disease prevention
Flowers & plants
Functional foods & nutraceuticals
Gallic acid
Health aspects
Honey
Honey - analysis
Humans
In vivo methods and tests
Inflammation
Natural products
Nervous system
neurodegenerative
Neurodegenerative Diseases - drug therapy
Neuroprotection
Neuroprotective Agents - therapeutic use
Parkinson's disease
Physiological aspects
Polyphenols
Polyphenols - therapeutic use
Quercetin
Review
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Summary:As the global population ages, there is an increasing research on managing neurodegenerative diseases that mainly affect the elderly. Honey is one of the natural products and functional foods widely studied for its neuroprotective properties. This review investigates honey's effectiveness as a neuroprotective agent through in vitro, in vivo, and clinical research. The articles were browsed from three databases (PubMed, ScienceDirect, and Scopus) between the years of 2012 and 2022 using the keywords "honey" crossed with "neurodegenerative". Out of the 16 articles, six in vitro, eight in vivo, one combination study, and one clinical intervention were compiled. Among the various types of honey studied, the Tualang and Thyme honey exhibited the highest antioxidant, anti-inflammatory, and anticholinesterase activity, leading to the prevention and management of multiple neurodegenerative diseases such as Alzheimer's disease. The neuroprotective properties of honey are primarily attributed to its high polyphenol content, with quercetin and gallic acid being the most prominent. This review compiled considerable evidence of the anti-neurodegenerative properties of honey presented by in vitro and in vivo studies. However, more clinical intervention studies are required to support these findings further.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15071558