Association of Common Variants of APOE , CETP , and the 9p21.3 Chromosomal Region with the Risk of Myocardial Infarction: A Prospective Study

• Published in: International journal of molecular sciences 2023-06, Vol.24 (13), p.10908
• Main Authors: Semaev, Sergey, Shakhtshneider, Elena, Shcherbakova, Liliya, Orlov, Pavel, Ivanoshchuk, Dinara, Malyutina, Sofia, Gafarov, Valery, Voevoda, Mikhail, Ragino, Yuliya
• Format: Article
• Language: English
• Subjects: Alleles; Apolipoprotein E; Apolipoproteins; Apolipoproteins E - genetics; Calcification; Cardiovascular disease; Cardiovascular diseases; CETP gene; Cholesterol; Cholesterol Ester Transfer Proteins - genetics; Coronary vessels; Gene frequency; Genes; Genetic factors; Genetic Predisposition to Disease; Genomes; Genotype; Genotype & phenotype; Health risk assessment; Heart attacks; High density lipoprotein; Humans; Lipoproteins; Male; Males; Meta-analysis; Myocardial infarction; Myocardial Infarction - genetics; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Prospective Studies; Risk; Risk Factors; rs1333049; rs429358; rs708272; rs7412
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241310908

The individual risk of an unfavorable cardiovascular outcome is determined by genetic factors in addition to lifestyle factors. This study was aimed at analyzing possible associations of several genetic factors with the risk of myocardial infarction (MI). For our study, we selected genes that have been significantly associated with MI in meta-analyses: the chromosomal region 9p21.3, the gene, and the gene. In total, 2286 randomly selected patients were included. Rs708272 and rs429358 and rs7412 were analyzed using RT-PCR via the TaqMan principle, and rs1333049 vas analyzed via a commercial KASP assay. In our sample, the frequencies of alleles and genotypes were consistent with frequencies in comparable populations of Eastern and Western Europe. Allele C of rs1333049 was significantly associated with MI among males ( = 0.027) and in the whole study sample ( = 0.008). We also revealed a significant association of the ɛ2/ɛ4 genotype of with MI among males ( < 0.0001) and in the whole study sample ( < 0.0001). Thus, among the tested polymorphisms, some genotypes of rs1333049 and rs429358 and rs7412 are the most strongly associated with MI and can be recommended for inclusion into a genetic risk score.