Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

• Published in: Biological procedures online 2024-06, Vol.26 (1), p.20-42, Article 20
• Main Authors: Muzammil, Khursheed, Rayyani, Saba, Abbas Sahib, Ahmed, Gholizadeh, Omid, Naji Sameer, Hayder, Jwad Kazem, Tareq, Badran Mohammed, Haneen, Ghafouri Kalajahi, Hesam, Zainul, Rahadian, Yasamineh, Saman
• Format: Article
• Language: English
• Subjects: Analysis; Animal models; Antibodies; Antigenic determinants; Antigens; Antiviral agents; Apoptosis; Arachnids; Biosensors; Biotechnology; Crimean hemorrhagic fever; Crimean-Congo hemorrhagic fever virus (CCHFV); Detection; Detectors; Enzyme-linked immunosorbent assay; Enzymes; Epitopes; Fever; Genomes; Health aspects; Hemorrhagic fever; Immunoglobulin G; Immunotherapy; Infection; Infections; Infectious diseases; Laboratories; Medical research; Medicine, Experimental; Polymerase chain reaction; Proteins; Recombinant proteins; Reverse transcription; Review; RNA polymerase; Tick-borne diseases; Treatment; Vaccination; Vaccines; Viruses; Zoonoses
• ISSN: 1480-9222; 1480-9222
• DOI: 10.1186/s12575-024-00244-3

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no specific clinical symptoms, mild to severe clinical symptoms, or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), and reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, and cheap technology, including biosensors, must be designed and developed to detect CCHFV. The goal of this article is to offer an overview of modern laboratory tests available as well as other innovative detection methods such as biosensors for CCHFV, as well as the benefits and limits of the assays. Furthermore, confirmed cases of CCHF are managed with symptomatic assistance and general supportive care. This study examined the various treatment modalities, as well as their respective limitations and developments, including immunotherapy and antivirals. Recent biotechnology advancements and the availability of suitable animal models have accelerated the development of CCHF vaccines by a substantial margin. We examined a range of potential vaccines for CCHF in this research, comprising nucleic acid, viral particles, inactivated, and multi-epitope vaccines, as well as the present obstacles and developments in this field. Thus, the purpose of this review is to present a comprehensive summary of the endeavors dedicated to advancing various diagnostic, therapeutic, and preventive strategies for CCHF infection in anticipation of forthcoming hazards.