MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia

BackgroundThe microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life. ObjectiveThe MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the asso...

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Bibliographic Details
Published in:Frontiers in nutrition (Lausanne) 2022-09, Vol.9, p.994607-994607
Main Authors: Eow, Shiang Yen, Gan, Wan Ying, Jiang, Tiemin, Loh, Su Peng, Lee, Ling Jun, Chin, Yit Siew, Than, Leslie Thian Lung, How, Kang Nien, Thong, Pui Ling, Liu, Yanpin, Zhao, Junying, Chen, Lijun
Format: Article
Language:English
Subjects:
asthma
birth cohort study
developmental delays
eczema
gastrointestinal disorders
microbiota
Nutrition
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Summary:BackgroundThe microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life. ObjectiveThe MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia. MethodsPregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum. DiscussionThis study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health. Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04919265.
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2022.994607