Performance and Determinants of Serum Creatinine and Cystatin C–Based GFR Estimating Equations in South Asians

The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) equation was calibrated for the general Pakistan population (eGFRcr-PK) to eliminate bias and improve accuracy. Cystatin C–based CKD-EPI equations (eGFRcys and eGFRcr-cys) hav...

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Bibliographic Details
Published in:Kidney international reports 2021-04, Vol.6 (4), p.962-975
Main Authors: Wang, Yeli, Levey, Andrew S., Inker, Lesley A., Jessani, Saleem, Bux, Rasool, Samad, Zainab, Khan, Ali Raza, Karger, Amy B., Allen, John C., Jafar, Tazeen H.
Format: Article
Language:English
Subjects:
Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
Clinical Research
cystatin C
estimating equations
glomerular filtration rate (GFR)
kidney function
South Asian
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Summary:The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) equation was calibrated for the general Pakistan population (eGFRcr-PK) to eliminate bias and improve accuracy. Cystatin C–based CKD-EPI equations (eGFRcys and eGFRcr-cys) have not been assessed in this population, and non-GFR determinants of cystatin C are unknown. We assessed eGFRcys, eGFRcr-cys, and non-GFR determinants of cystatin C in a cross-sectional study of 557 participants (≥40 years of age) from Pakistan. We compared bias (median difference in measured GFR [mGFR] and eGFR), precision (interquartile range [IQR] of differences), accuracy (percentage of eGFR within 30% of mGFR), root mean square error (RMSE), and classification of mGFR 
ISSN:2468-0249
2468-0249
DOI:10.1016/j.ekir.2021.01.005