A rapid multi-parametric quantitative MR imaging method to assess Parkinson's disease: a feasibility study

MULTIPLEX is a single-scan three-dimensional multi-parametric MRI technique that provides 1 mm isotropic T1-, T2*-, proton density- and susceptibility-weighted images and the corresponding quantitative maps. This study aimed to investigate its feasibility of clinical application in Parkinson's...

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Bibliographic Details
Published in:BMC medical imaging 2024-03, Vol.24 (1), p.58-58, Article 58
Main Authors: Duan, Min, Pan, Rongrong, Gao, Qing, Wu, Xinying, Lin, Hai, Yuan, Jianmin, Zhang, Yamei, Liu, Lindong, Tian, Youyong, Fu, Tong
Format: Article
Language:English
Subjects:
Abnormalities
Data processing
Diagnosis
Disease
Dopamine
Dopamine receptors
Dopaminergic midbrain nuclei
Feasibility Studies
Humans
Image processing
Image reconstruction
Magnetic resonance imaging
Medical imaging
Medical research
Medicine, Experimental
Mesencephalon
Methods
Movement disorders
Multi-parametric MRI
Multiparametric Magnetic Resonance Imaging
Multiplexing
Neurodegenerative diseases
Neuroimaging
Neurons
Nuclei
Parameter identification
Parkinson Disease - diagnostic imaging
Parkinson's disease
Pathology
Proton density (concentration)
Protons
Quantitative imaging
Somatotropin
Subcortical nuclei
Substantia nigra
Subthalamic nucleus
Telecommunications equipment industry
Therapeutic applications
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Summary:MULTIPLEX is a single-scan three-dimensional multi-parametric MRI technique that provides 1 mm isotropic T1-, T2*-, proton density- and susceptibility-weighted images and the corresponding quantitative maps. This study aimed to investigate its feasibility of clinical application in Parkinson's disease (PD). 27 PD patients and 23 healthy control (HC) were recruited and underwent a MULTIPLEX scanning. All image reconstruction and processing were automatically performed with in-house C + + programs on the Automatic Differentiation using Expression Template platform. According to the HybraPD atlas consisting of 12 human brain subcortical nuclei, the region-of-interest (ROI) based analysis was conducted to extract quantitative parameters, then identify PD-related abnormalities from the T1, T2* and proton density maps and quantitative susceptibility mapping (QSM), by comparing patients and HCs. The ROI-based analysis revealed significantly decreased mean T1 values in substantia nigra pars compacta and habenular nuclei, mean T2* value in subthalamic nucleus and increased mean QSM value in subthalamic nucleus in PD patients, compared to HCs (all p values 
ISSN:1471-2342
1471-2342
DOI:10.1186/s12880-024-01229-0