Distinguishing clinical characteristics of central nervous system tuberculosis in immunodeficient and non-immunodeficient individuals: a 12-year retrospective study

Central nervous system tuberculosis (CNS TB) is a severe Mycobacterium tuberculosis (MTB) infection. It is unclear whether a patient's immune status alters the clinical manifestations and treatment outcomes of CNS TB. Between January 2007-December 2018, chart reviews of CNS TB, including tuberc...

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Bibliographic Details
Published in:Annals of clinical microbiology and antimicrobials 2023-08, Vol.22 (1), p.69-69, Article 69
Main Authors: Saifon, Woraseth, Karaketklang, Khemajira, Jitmuang, Anupop
Format: Article
Language:English
Subjects:
Abscess
Abscesses
Acids
Adult
Age
Blood cell count
Care and treatment
Central nervous system
Cerebrospinal fluid
Clinical outcomes
Complications and side effects
Demographic aspects
Diagnosis
Female
Health aspects
Hemoglobin
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Immune status
Immunodeficiency
Infections
Leukocytes
Male
Meningitis
Middle Aged
Mortality
Multidrug resistance
Mycobacterium tuberculosis
Myelitis
Nervous system
Patients
Pulmonary tuberculosis
Radiography
Retrospective Studies
Sample size
Spinal cord
Tuberculoma
Tuberculoma - complications
Tuberculosis
Tuberculosis, Central Nervous System - complications
Tuberculosis, Central Nervous System - diagnosis
Tuberculosis, Central Nervous System - drug therapy
Tuberculosis, Meningeal - complications
Tuberculosis, Meningeal - diagnosis
Tuberculosis, Meningeal - drug therapy
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Summary:Central nervous system tuberculosis (CNS TB) is a severe Mycobacterium tuberculosis (MTB) infection. It is unclear whether a patient's immune status alters the clinical manifestations and treatment outcomes of CNS TB. Between January 2007-December 2018, chart reviews of CNS TB, including tuberculous meningitis (TBM), tuberculoma/abscess, and TB myelitis, were made. Subjects were categorized as immunodeficient (ID) and non-immunodeficient (NID). Of 310 subjects, 160 (51.6%) were in the ID group-132 (42.6%) had HIV and 28 (9.0%) had another ID, and 150 (48.4%) were in the NID group. The mean age was 43.64 ± 16.76 years, and 188 (60.6%) were male. There were 285 (91.9%) TBM, 16 (5.2%) tuberculoma/abscess, and 9 (2.9%) myelitis cases. The TBM characteristics in the ID group were younger age (p = 0.003), deep subcortical location of tuberculoma (p = 0.030), lower hemoglobin level (p 
ISSN:1476-0711
1476-0711
DOI:10.1186/s12941-023-00615-w