Wireless neuromodulation in vitro and in vivo by intrinsic TRPC-mediated magnetomechanical stimulation

Various magnetic deep brain stimulation (DBS) methods have been developing rapidly in the last decade for minimizing the invasiveness of DBS. However, current magnetic DBS methods, such as magnetothermal and magnetomechanical stimulation, require overexpressing exogeneous ion channels in the central...

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Bibliographic Details
Published in:Communications biology 2022-11, Vol.5 (1), p.1166-1166, Article 1166
Main Authors: Su, Chih-Lun, Cheng, Chao-Chun, Yen, Ping-Hsiang, Huang, Jun-Xuan, Ting, Yen-Jing, Chiang, Po-Han
Format: Article
Language:English
Subjects:
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Biology
Biomedical and Life Sciences
c-Fos protein
Central nervous system
Deep Brain Stimulation
Invasiveness
Ion channels
Life Sciences
Neuromodulation
Neurons - physiology
Proto-Oncogene Proteins c-fos - metabolism
Transient Receptor Potential Channels
Transient receptor potential proteins
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Summary:Various magnetic deep brain stimulation (DBS) methods have been developing rapidly in the last decade for minimizing the invasiveness of DBS. However, current magnetic DBS methods, such as magnetothermal and magnetomechanical stimulation, require overexpressing exogeneous ion channels in the central nervous system (CNS). It is unclear whether magnetomechanical stimulation can modulate non-transgenic CNS neurons or not. Here, we reveal that the torque of magnetic nanodiscs with weak and slow alternative magnetic field (50 mT at 10 Hz) could activate neurons through the intrinsic transient receptor potential canonical channels (TRPC), which are mechanosensitive ion channels widely expressed in the brain. The immunostaining with c-fos shows the increasement of neuronal activity by wireless DBS with magnetomechanical approach in vivo. Overall, this research demonstrates a magnetic nanodiscs-based magnetomechanical approach that can be used for wireless neuronal stimulation in vitro and untethered DBS in vivo without implants or genetic manipulation. A magnetic nanodiscs-based magnetomechanical approach is presented that can be used for wireless neuronal stimulation in vitro and untethered deep brain stimulation in vivo without implants or genetic manipulation.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-022-04124-y