Integrated network analysis identifying potential novel drug candidates and targets for Parkinson's disease

This study aimed to identify potential novel drug candidates and targets for Parkinson’s disease. First, 970 genes that have been reported to be related to PD were collected from five databases, and functional enrichment analysis of these genes was conducted to investigate their potential mechanisms...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.13154-13154, Article 13154
Main Authors: Quan, Pusheng, Wang, Kai, Yan, Shi, Wen, Shirong, Wei, Chengqun, Zhang, Xinyu, Cao, Jingwei, Yao, Lifen
Format: Article
Language:English
Subjects:
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Candidates
Drug development
Drugs
Gene expression
Gene set enrichment analysis
Humanities and Social Sciences
Movement disorders
multidisciplinary
Neurodegenerative diseases
Parkinson's disease
Science
Science (multidisciplinary)
Therapeutic targets
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Summary:This study aimed to identify potential novel drug candidates and targets for Parkinson’s disease. First, 970 genes that have been reported to be related to PD were collected from five databases, and functional enrichment analysis of these genes was conducted to investigate their potential mechanisms. Then, we collected drugs and related targets from DrugBank, narrowed the list by proximity scores and Inverted Gene Set Enrichment analysis of drug targets, and identified potential drug candidates for PD treatment. Finally, we compared the expression distribution of the candidate drug-target genes between the PD group and the control group in the public dataset with the largest sample size (GSE99039) in Gene Expression Omnibus. Ten drugs with an FDR 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92701-2