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The effect of metformin usage on survival outcomes for hepatocellular carcinoma patients with type 2 diabetes mellitus after curative therapy

Metformin has attracted more attention from researchers for its newly discovered antitumor effects. A meta-analysis was performed to reveal the efficacy of metformin on overall survival (OS) and recurrence-free survival (RFS) for HCC patients with type 2 diabetes mellitus (T2DM) after curative treat...

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Published in:Frontiers in endocrinology (Lausanne) 2022-12, Vol.13, p.1060768-1060768
Main Authors: Yuan, Bo, Ma, Jichun, Wang, Jing, Hao, Jinyong
Format: Article
Language:English
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Summary:Metformin has attracted more attention from researchers for its newly discovered antitumor effects. A meta-analysis was performed to reveal the efficacy of metformin on overall survival (OS) and recurrence-free survival (RFS) for HCC patients with type 2 diabetes mellitus (T2DM) after curative treatment. Databases including PubMed, the Cochrane Library, Web of Science, CNKI, Wangfang, and Weipu Database up until 31 May 2022 were searched for relevant studies. STATA 13.0 was used to perform the meta-analysis. A total of six studies involving 5,936 patients were included in our study. The results from the current study revealed that metformin usage can significantly prolong the 3-year [odds ratio (OR) = 1.50, 95% confidence interval (CI): 1.22-1.83, = 0.000] and 5-year (OR = 1.88, 95% CI: 1.47-2.41, = 0.000) OS and decrease the 1-year (OR = 1.31, 95% CI: 1.08-1.59, = 0.007), 3-year (OR = 1.88, 95% CI: 1.48-2.37, = 0.000), and 5-year (OR = 1.83, 95% CI: 1.40-2.40, = 0.000) recurrence rates. Metformin treatment significantly prolongs the OS and decreases the recurrence rate for HCC patients with T2DM after curative HCC therapy.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.1060768