The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals

Obesity has become a common human disorder associated with significant morbidity and mortality and adverse effects on quality of life. Sequence variants in two candidate genes, FTO and UCP-1, have been reported to be overrepresented in obese Caucasian population. The association of these genes polym...

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Bibliographic Details
Published in:BMC genetics 2012-11, Vol.13 (1), p.101-101
Main Authors: Ramos, Adauto V, Bastos-Rodrigues, Luciana, Resende, Bruna A, Friedman, Eitan, Campanha-Versiani, Luciana, Miranda, Debora M, Sarquis, Marta, De Marco, Luiz
Format: Article
Language:English
Subjects:
Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Brazil
Brazilian population
Cardiovascular Diseases - genetics
Case-Control Studies
Diabetes Mellitus - genetics
Female
FTO
Genes
Genetic Predisposition to Disease
Genetics
Humans
Ion Channels - genetics
Male
Middle Aged
Mitochondrial Proteins - genetics
Morbid obesity
Multiethnic sample
Obesity
Obesity, Morbid - genetics
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
Risk Factors
UCP-1
Uncoupling Protein 1
Weight control
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Summary:Obesity has become a common human disorder associated with significant morbidity and mortality and adverse effects on quality of life. Sequence variants in two candidate genes, FTO and UCP-1, have been reported to be overrepresented in obese Caucasian population. The association of these genes polymorphisms with the obesity phenotype in a multiethnic group such as the Brazilian population has not been previously reported. To assess the putative contribution of both FTO and UCP-1 to body mass index (BMI) and cardiovascular risk we genotyped SNPs rs9939609 (FTO) and rs6536991, rs22705565 and rs12502572 (UCP-1) from 126 morbidly obese subjects (BMI 42.9 ± 5.6 kg/m2, mean ± SE) and 113 normal-weight ethnically matched controls (BMI 22.6 ± 3.5 kg/m2, mean ± SE). Waist circumference, blood pressure, glucose and serum lipids were also measured. Each sample was also genotyped for 40 biallelic short insertion/deletion polymorphism (indels) for ethnic assignment and to estimate the proportion of European, African and Amerindian biogeographical ancestry in the Brazilian population. Cases did not differ from controls in the proportions of genomic ancestry. The FTO SNP rs9939609 and UCP-1 SNP rs6536991 were significantly associated with BMI (p= 0.04 and p
ISSN:1471-2156
1471-2350
1471-2350
1471-2156
DOI:10.1186/1471-2350-13-101