A systematic review: the current status of carbapenem resistance in East Africa

In this systematic review, we present the molecular epidemiology and knowledge gaps of the carbapenem resistance in East Africa as well as the future probable research interventions that can be used to address the emergence of carbapenem resistance in the region. The 17 articles which presented conc...

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Bibliographic Details
Published in:BMC research notes 2018-08, Vol.11 (1), p.629-629, Article 629
Main Authors: Ssekatawa, Kenneth, Byarugaba, Dennis K, Wampande, Edward, Ejobi, Francis
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Africa, Eastern
Analysis
Anti-Bacterial Agents
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Bacterial pneumonia
beta-Lactamases
Carbapenem resistance
Carbapenems
Carbapenems - pharmacology
Drug resistance
Drug Resistance, Bacterial
E coli
East Africa
Epidemiology
Escherichia coli
Hospitals
Humans
Infections
Infectious diseases
Microbial Sensitivity Tests
Molecular epidemiology
Pneumonia
Research Note
Respiratory tract
Studies
Systematic review
Urine
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Summary:In this systematic review, we present the molecular epidemiology and knowledge gaps of the carbapenem resistance in East Africa as well as the future probable research interventions that can be used to address the emergence of carbapenem resistance in the region. The 17 articles which presented concrete information about the prevalence of carbapenem resistance in East Africa were reviewed. Tanzania exhibited the highest level of carbapenem resistance at 35% while DRC had the lowest level at 0.96%. Uganda was the only country with studies documenting CR obtained amongst hospital environment isolates with incidence ranging from 21% in Pseudomonas aeruginosa to 55% in Acinetobacter baumannii. Carbapenem resistance was more exhibited in A. baumannii (23%), followed by P. aeruginosa (17%), Klebsiella pneumoniae (15%), Proteus mirabilis (14%) and Escherichia coli (12%) mainly isolated from respiratory tract, blood, urine and wound/pus. The regional genetic determinants of carbapenem resistance detected were blaIMP, blaVIM-1 blaSPM-l, blaNDM-1, blaOXA-23 blaOXA-24, blaOXA-58 and blaKPC.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-018-3738-2