Mitochondrial K+ Transport: Modulation and Functional Consequences

The existence of a K+ cycle in mitochondria has been predicted since the development of the chemiosmotic theory and has been shown to be crucial for several cellular phenomena, including regulation of mitochondrial volume and redox state. One of the pathways known to participate in K+ cycling is the...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (10), p.2935
Main Authors: Pereira, Osvaldo, Kowaltowski, Alicia J.
Format: Article
Language:English
Subjects:
activation
Chemiosmotic theory
drugs
Experiments
Homeostasis
inhibition
Ischemia
Kinases
Metabolism
Mitochondria
Phosphorylation
Physiology
potassium
Potassium channels
Proteins
Redox properties
Reperfusion
Review
transport
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Summary:The existence of a K+ cycle in mitochondria has been predicted since the development of the chemiosmotic theory and has been shown to be crucial for several cellular phenomena, including regulation of mitochondrial volume and redox state. One of the pathways known to participate in K+ cycling is the ATP-sensitive K+ channel, MitoKATP. This channel was vastly studied for promoting protection against ischemia reperfusion when pharmacologically activated, although its molecular identity remained unknown for decades. The recent molecular characterization of MitoKATP has opened new possibilities for modulation of this channel as a mechanism to control cellular processes. Here, we discuss different strategies to control MitoKATP activity and consider how these could be used as tools to regulate metabolism and cellular events.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26102935