How to reset metabolic setpoint in obesity management

The metabolic setpoint theory is based upon the premise that there is a barohomeostatic mechanism in humans which maintains weight within a predetermined range. This is viewed as an obstacle to weight loss, but can also be considered an opportunity to reset the barometabolic setpoint. This expert cl...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2022-02, Vol.72 (2), p.375-376
Main Authors: Kalra, Sanjay, Arora, Saurabh, Kapoor, Nitin
Format: Article
Language:English
Subjects:
Body weight
Care and treatment
Health aspects
Homeostasis
Humans
Medical care
Metabolic regulation
Methods
Needs assessment
Obesity
Obesity Management
Weight Loss
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Summary:The metabolic setpoint theory is based upon the premise that there is a barohomeostatic mechanism in humans which maintains weight within a predetermined range. This is viewed as an obstacle to weight loss, but can also be considered an opportunity to reset the barometabolic setpoint. This expert clinical opinion piece shares pragmatic suggestions on how to achieve this. Initiating with monotherapy, titrating dosage gradually, inter-changing treatment if needed, troubleshooting where necessary and intensifying slowly to combination therapy help reset the barometabolic homeostatic range.
ISSN:0030-9982
DOI:10.47391/JPMA.22-37