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Review: Advanced Atomic Force Microscopy Modes for Biomedical Research
Visualization of biomedical samples in their native environments at the microscopic scale is crucial for studying fundamental principles and discovering biomedical systems with complex interaction. The study of dynamic biological processes requires a microscope system with multiple modalities, high...
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| Published in: | Biosensors (Basel) 2022-12, Vol.12 (12), p.1116 |
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| Language: | English |
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| container_title | Biosensors (Basel) |
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| creator | Xia, Fangzhou Youcef-Toumi, Kamal |
| description | Visualization of biomedical samples in their native environments at the microscopic scale is crucial for studying fundamental principles and discovering biomedical systems with complex interaction. The study of dynamic biological processes requires a microscope system with multiple modalities, high spatial/temporal resolution, large imaging ranges, versatile imaging environments and ideally in-situ manipulation capabilities. Recent development of new Atomic Force Microscopy (AFM) capabilities has made it such a powerful tool for biological and biomedical research. This review introduces novel AFM functionalities including high-speed imaging for dynamic process visualization, mechanobiology with force spectroscopy, molecular species characterization, and AFM nano-manipulation. These capabilities enable many new possibilities for novel scientific research and allow scientists to observe and explore processes at the nanoscale like never before. Selected application examples from recent studies are provided to demonstrate the effectiveness of these AFM techniques. |
| doi_str_mv | 10.3390/bios12121116 |
| format | article |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| source | Publicly Available Content Database; PubMed Central; Coronavirus Research Database |
| subjects | Atomic force microscopy Biological activity Biomedical Research Care and treatment Diagnosis high-speed imaging Imaging Innovations Light material property mapping mechanobiology Medical research Medicine, Experimental Microorganisms Microscopes Microscopy Microscopy, Atomic Force - methods nano-manipulation nanotechnology Nanotechnology - methods Review Spectroscopy Technology application Temporal resolution Topography Virus diseases Viruses Visualization |
| title | Review: Advanced Atomic Force Microscopy Modes for Biomedical Research |
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