Evaluation of Naringenin as a Promising Treatment Option for COPD Based on Literature Review and Network Pharmacology

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacologi...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2020-12, Vol.10 (12), p.1644
Main Authors: Chen, Zhen, Chen, Pan, Wu, Hao, Shi, Rui, Su, Weiwei, Wang, Yonggang, Li, Peibo
Format: Article
Language:English
Subjects:
Asthma
Bioavailability
Bronchitis
Chemokines
Chronic obstructive pulmonary disease
COPD
Cytokines
Disease
Drug dosages
Inflammation
Kinases
Literature reviews
Lung diseases
Lungs
mechanism
Morbidity
Naringenin
Obstructive lung disease
Oxidative stress
Pathogenesis
Pharmacology
Proteins
Respiratory diseases
Review
Tumor necrosis factor-TNF
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Summary:Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacological activities against multiple pathological stages of COPD, but available studies are scattered and unsystematic. Thus, we combined literature review with network pharmacology analysis to evaluate the potential therapeutic effects of naringenin on COPD and predict its underlying mechanisms, expecting to provide a promising tactic for clinical treatment of COPD.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom10121644