Cellular components in tumor microenvironment of neuroblastoma and the prognostic value

Tumor microenvironment (TME) contributes to tumor development, progression, and treatment response. In this study, we detailed the cell composition of the TME in neuroblastoma (NB) and constructed a cell risk score model to predict the prognosis of NB. xCell score was calculated through transcriptom...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2019-12, Vol.7, p.e8017-e8017, Article e8017
Main Authors: Zhong, Xiaodan, Zhang, Yutong, Wang, Linyu, Zhang, Hao, Liu, Haiming, Liu, Yuanning
Format: Article
Language:English
Subjects:
Algorithms
Analysis
Bioinformatics
Cancer therapies
Clinical outcomes
Datasets
Dendritic cells
Development and progression
Gene expression
Genes
Lymphocytes
Medical prognosis
Melanoma
Neuroblastoma
Oncology
Patients
pCRS
Prognosis
Regression analysis
Risk groups
Risk score
Smooth muscle
Stem cells
Tumor microenvironment
Tumors
xCell
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Summary:Tumor microenvironment (TME) contributes to tumor development, progression, and treatment response. In this study, we detailed the cell composition of the TME in neuroblastoma (NB) and constructed a cell risk score model to predict the prognosis of NB. xCell score was calculated through transcriptomic data from the datasets GSE49711 and GSE45480 based on the xCell algorithm. The random forest method was employed to select important features and the coefficient was obtained via multivariate cox regression analysis to construct a prognostic model, and the performance was validated in another two independent datasets, GSE16476 and TARGET-NBL. We found that both immune and non-immune cells varies significantly in different prognostic groups, and were correlated with survival time. The proposed prognostic cell risk score (pCRS) model we constructed can be an independent prognostic indicator for overall survival (OS) and event-free survival (EFS) (training: OS, HR 1.579, EFS, HR 1.563; validation: OS, HR 1.665, 3.848, EFS, HR 2.203, all -values 
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.8017