Suppression of carrageenan- and collagen II-induced inflammation in mice by geranium oil

To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. S...

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Bibliographic Details
Published in:Mediators of inflammation 2006, Vol.2006 (3), p.62537-7
Main Authors: MARUYAMA, Naho, ISHIBASHI, Hiroko, WEIMIN HU, MOROFUJI, Shinichiro, INOUYE, Shigeharu, YAMAGUCHI, Hideyo, ABE, Shigeru
Format: Article
Language:English
Subjects:
Animals
Aromatherapy
Arthritis, Experimental - prevention & control
Biological and medical sciences
Care and treatment
Carrageenan
Collagen Type II - immunology
Essences and essential oils
Fundamental and applied biological sciences. Psychology
Geranium
Health aspects
Inflammation
Inflammation - prevention & control
Male
Mice
Mice, Inbred DBA
Molecular and cellular biology
Oils, Volatile - therapeutic use
Peroxidase - metabolism
Research Communication
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Summary:To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.
ISSN:0962-9351
1466-1861
DOI:10.1155/mi/2006/62537