Effects of Lead Toxicity on Spermatogenesis in the Testes of Albino Rats

Objective: The objective of this study was to observe changes in spermatogenesis in the testes of albino rats exposed to lead acetate. Study Design: An experimental animals study Place of Study and Duration: This study was carried out in the Department of Anatomy, Islamic International Medical Colle...

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Bibliographic Details
Published in:J. Islamic Int. Med. Coll. 2011-07, Vol.6 (1), p.33-36
Main Author: Dr. Saffia Shaukat, Dr. Shabana Ali, Dr. Fatima Riaz
Format: Article
Language:English
Subjects:
spermatogenesis, lead toxicity, rat fertility
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Summary:Objective: The objective of this study was to observe changes in spermatogenesis in the testes of albino rats exposed to lead acetate. Study Design: An experimental animals study Place of Study and Duration: This study was carried out in the Department of Anatomy, Islamic International Medical College Rawalpindi and at National Institute of Health Islamabad from January to April, 2009. Materials and Methods: Male adult rats were exposed to lead acetate with intraperitoneal dose of 4mg/Kg body weight for 5 days a week for 6 weeks. The animals in groupAwere used as control. The animals of groups B were treated with lead acetate with specified dose for 6 weeks. After 6 weeks the animals of subgroup B were sacrificed. The results of these two groups were then compared. Results: After six weeks, it was observed that the number of spermatogenic cells had decreased in the test groups as compared with control group (p
ISSN:1815-4018
2410-5422