Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients

Amiodarone is a widely used agent for life-threatening arrhythmias. Although amiodarone-induced thyrotoxicosis (AIT) is a major adverse effect that can cause recurrence of arrhythmias and exacerbation of heart failure, risk factors for AIT among amiodarone-treated Japanese patients have not been elu...

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Bibliographic Details
Published in:International Journal of Endocrinology 2014-01, Vol.2014 (2014), p.65-70-107
Main Authors: Fujitani, Yoshio, Daida, Hiroyuki, Watada, Hirotaka, Shimada, Kazunori, Shigihara, Nayumi, Takeno, Kageumi, Komiya, Koji, Sekita, Gaku, Takagi, Atsutoshi, Kasai, T., Uchida, Toyoyoshi, Miyauchi, Katsumi
Format: Article
Language:English
Subjects:
Age
Amiodarone
Angina pectoris
Cardiac arrhythmia
Cardiovascular disease
Complications and side effects
Demographic aspects
Development and progression
Dosage and administration
Drug dosages
Endocrinology
Gender
Health risk assessment
Heart failure
Iodine
Males
Patients
Pneumonia
Prevalence studies (Epidemiology)
Regression analysis
Risk factors
Studies
Thyroid diseases
Thyroid gland
Ultrasonic imaging
Variables
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Summary:Amiodarone is a widely used agent for life-threatening arrhythmias. Although amiodarone-induced thyrotoxicosis (AIT) is a major adverse effect that can cause recurrence of arrhythmias and exacerbation of heart failure, risk factors for AIT among amiodarone-treated Japanese patients have not been elucidated. Here, we investigated the prevalence and predictive factors for AIT. The study subjects were 225 patients treated with amiodarone between 2008 and 2012, who were euthyroid before amiodarone therapy. All patients with AIT were diagnosed by measurement of thyroid hormones and ultrasonography. Among the 225 subjects, 13 patients (5.8%) developed AIT and all the patients were classified as Type 2 AIT. Baseline features of patients with AIT were not different from those who did not develop AIT, except for age (AIT, 55.1 ± 13.8, non-AIT, 68.1 ± 12.0 years, P < 0.001 ). Multivariate analyses using the Cox proportional hazard model identified age as the sole determinant of AIT (hazard ratio: 0.927, 95% confidence interval: 0.891–0.964). Receiver operating characteristic curve analysis identified age of 63.5 years as the cutoff value for AIT with sensitivity of 70.3% and specificity of 69.2%. In summary, this study showed that the prevalence of AIT is 5.8% in Japanese patients treated with amiodarone and that young age is a risk factor for AIT.
ISSN:1687-8337
1687-8345
DOI:10.1155/2014/534904