Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

Field-effect transistor (FET) is regarded as the most promising candidate for the next-generation biosensor, benefiting from the advantages of label-free, easy operation, low cost, easy integration, and direct detection of biomarkers in liquid environments. With the burgeoning advances in nanotechno...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2023-04, Vol.21 (1), p.144-144, Article 144
Main Authors: Chen, Shuo, Sun, Yang, Fan, Xiangyu, Xu, Yazhe, Chen, Shanshan, Zhang, Xinhao, Man, Baoyuan, Yang, Cheng, Du, Jun
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Biomarker detection
Biomarkers
Biomolecules
Biosensing Techniques - methods
Biosensor
Biosensors
Biotechnology
Field effect transistors
Field-effect transistor
Graphene
Health aspects
Medical equipment
Nanomaterials
Nanotechnology
Optimization
Physiological apparatus
Researchers
Review
Semiconductor devices
Sensing application
Sensors
Signal processing
Transistors
Transistors, Electronic
Two dimensional materials
Two-Dimensional Material
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Summary:Field-effect transistor (FET) is regarded as the most promising candidate for the next-generation biosensor, benefiting from the advantages of label-free, easy operation, low cost, easy integration, and direct detection of biomarkers in liquid environments. With the burgeoning advances in nanotechnology and biotechnology, researchers are trying to improve the sensitivity of FET biosensors and broaden their application scenarios from multiple strategies. In order to enable researchers to understand and apply FET biosensors deeply, focusing on the multidisciplinary technical details, the iteration and evolution of FET biosensors are reviewed from exploring the sensing mechanism in detecting biomolecules (research direction 1), the response signal type (research direction 2), the sensing performance optimization (research direction 3), and the integration strategy (research direction 4). Aiming at each research direction, forward perspectives and dialectical evaluations are summarized to enlighten rewarding investigations.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-023-01898-z