Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling

Inflammatory bowel disease (IBD), a common term for Crohn's disease and ulcerative colitis, is a chronic, relapse-remitting condition of the gastrointestinal tract that is increasing worldwide. Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2024-01, Vol.13 (2), p.177
Main Authors: Fakhfouri, Gohar, Mijailović, Nataša R, Rahimian, Reza
Format: Article
Language:English
Subjects:
Anxiety
Bacteria
Behavior
Colitis, Ulcerative
Communication
Comorbidity
Complications and side effects
Crohn's disease
Cytokines
Gastrointestinal tract
gut microbiota
gut–brain axis
Humans
IBD
Immune response
Immune system
Inflammation
Inflammatory bowel disease
Inflammatory Bowel Diseases
Innate immunity
Intestine
Kinases
Mental depression
Mental disorders
Mental illness
Metabolites
Microbiota
Microglia
Neurogenesis
neuroinflammation
Pathogenesis
Permeability
Phagocytes
Physiology
psychiatric disorders
Psychological aspects
Quality of life
Risk factors
Tumor necrosis factor-TNF
Ulcerative colitis
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Summary:Inflammatory bowel disease (IBD), a common term for Crohn's disease and ulcerative colitis, is a chronic, relapse-remitting condition of the gastrointestinal tract that is increasing worldwide. Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than in healthy individuals. Evidence suggests that varying levels of neuroinflammation might underlie these states in IBD patients. Within this context, microglia are the crucial non-neural cells in the brain responsible for innate immune responses following inflammatory insults. Alterations in microglia's functions, such as secretory profile, phagocytic activity, and synaptic pruning, might play significant roles in mediating psychiatric manifestations of IBD. In this review, we discuss the role played by microglia in IBD-associated comorbidities.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13020177