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Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling
Inflammatory bowel disease (IBD), a common term for Crohn's disease and ulcerative colitis, is a chronic, relapse-remitting condition of the gastrointestinal tract that is increasing worldwide. Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than...
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| Published in: | Cells (Basel, Switzerland) Switzerland), 2024-01, Vol.13 (2), p.177 |
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| container_title | Cells (Basel, Switzerland) |
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| creator | Fakhfouri, Gohar Mijailović, Nataša R Rahimian, Reza |
| description | Inflammatory bowel disease (IBD), a common term for Crohn's disease and ulcerative colitis, is a chronic, relapse-remitting condition of the gastrointestinal tract that is increasing worldwide. Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than in healthy individuals. Evidence suggests that varying levels of neuroinflammation might underlie these states in IBD patients. Within this context, microglia are the crucial non-neural cells in the brain responsible for innate immune responses following inflammatory insults. Alterations in microglia's functions, such as secretory profile, phagocytic activity, and synaptic pruning, might play significant roles in mediating psychiatric manifestations of IBD. In this review, we discuss the role played by microglia in IBD-associated comorbidities. |
| doi_str_mv | 10.3390/cells13020177 |
| format | article |
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Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than in healthy individuals. Evidence suggests that varying levels of neuroinflammation might underlie these states in IBD patients. Within this context, microglia are the crucial non-neural cells in the brain responsible for innate immune responses following inflammatory insults. Alterations in microglia's functions, such as secretory profile, phagocytic activity, and synaptic pruning, might play significant roles in mediating psychiatric manifestations of IBD. In this review, we discuss the role played by microglia in IBD-associated comorbidities.</description><identifier>ISSN: 2073-4409</identifier><identifier>EISSN: 2073-4409</identifier><identifier>DOI: 10.3390/cells13020177</identifier><identifier>PMID: 38247868</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anxiety ; Bacteria ; Behavior ; Colitis, Ulcerative ; Communication ; Comorbidity ; Complications and side effects ; Crohn's disease ; Cytokines ; Gastrointestinal tract ; gut microbiota ; gut–brain axis ; Humans ; IBD ; Immune response ; Immune system ; Inflammation ; Inflammatory bowel disease ; Inflammatory Bowel Diseases ; Innate immunity ; Intestine ; Kinases ; Mental depression ; Mental disorders ; Mental illness ; Metabolites ; Microbiota ; Microglia ; Neurogenesis ; neuroinflammation ; Pathogenesis ; Permeability ; Phagocytes ; Physiology ; psychiatric disorders ; Psychological aspects ; Quality of life ; Risk factors ; Tumor necrosis factor-TNF ; Ulcerative colitis</subject><ispartof>Cells (Basel, Switzerland), 2024-01, Vol.13 (2), p.177</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than in healthy individuals. Evidence suggests that varying levels of neuroinflammation might underlie these states in IBD patients. Within this context, microglia are the crucial non-neural cells in the brain responsible for innate immune responses following inflammatory insults. Alterations in microglia's functions, such as secretory profile, phagocytic activity, and synaptic pruning, might play significant roles in mediating psychiatric manifestations of IBD. In this review, we discuss the role played by microglia in IBD-associated comorbidities.</description><subject>Anxiety</subject><subject>Bacteria</subject><subject>Behavior</subject><subject>Colitis, Ulcerative</subject><subject>Communication</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Crohn's disease</subject><subject>Cytokines</subject><subject>Gastrointestinal tract</subject><subject>gut microbiota</subject><subject>gut–brain axis</subject><subject>Humans</subject><subject>IBD</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases</subject><subject>Innate immunity</subject><subject>Intestine</subject><subject>Kinases</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental illness</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Microglia</subject><subject>Neurogenesis</subject><subject>neuroinflammation</subject><subject>Pathogenesis</subject><subject>Permeability</subject><subject>Phagocytes</subject><subject>Physiology</subject><subject>psychiatric disorders</subject><subject>Psychological aspects</subject><subject>Quality of life</subject><subject>Risk factors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ulcerative colitis</subject><issn>2073-4409</issn><issn>2073-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks1v1DAQxSMEolXpkSuyxAEuKf6MbW5loSVSKzjAOXKc8eJVEhfbEdr_HqfbFoqwD7ZGv3n2G72qeknwGWMav7MwjokwTDGR8kl1TLFkNedYP_3rflSdprTDZSnSECyeV0dMUS5Vo46r_mva2x_e5Ogt2oQpxN4PPntIKDjUzm4002RyiHv0IfyCEX30CUyC96jNqE3IoGuTM8SVvvY2hu3ozZuELpeMLgBGP29fVM-cGROc3p0n1feLT982n-urL5ft5vyqtlyzXBPNDZjGWeU0YYLghlFLCeVWNw4Elo4zbIjS1AoGrtemGNA9d5yoxjWMnVTtQXcIZtfdRD-ZuO-C8d1tIcRtZ2L2doROG4elHAQnqwATfS8GTQfVgISeKFu03h60bmL4uUDK3eTTOm0zQ1hSRzWRQmiqREFf_4PuwhLn4nSllOCUafWH2pryvp9dyNHYVbQ7lworyaiihTr7D1X2AJO3YQbnS_1RQ31oKJNPKYJ78E1wt0akexSRwr-6--zSTzA80PeBYL8BgeCzRQ</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Fakhfouri, Gohar</creator><creator>Mijailović, Nataša R</creator><creator>Rahimian, Reza</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2125-0565</orcidid><orcidid>https://orcid.org/0000-0002-3509-0400</orcidid><orcidid>https://orcid.org/0000-0003-0829-2143</orcidid></search><sort><creationdate>20240101</creationdate><title>Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling</title><author>Fakhfouri, Gohar ; 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Psychiatric comorbidities, including depression and anxiety, are more prevalent in IBD patients than in healthy individuals. Evidence suggests that varying levels of neuroinflammation might underlie these states in IBD patients. Within this context, microglia are the crucial non-neural cells in the brain responsible for innate immune responses following inflammatory insults. Alterations in microglia's functions, such as secretory profile, phagocytic activity, and synaptic pruning, might play significant roles in mediating psychiatric manifestations of IBD. In this review, we discuss the role played by microglia in IBD-associated comorbidities.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38247868</pmid><doi>10.3390/cells13020177</doi><orcidid>https://orcid.org/0000-0002-2125-0565</orcidid><orcidid>https://orcid.org/0000-0002-3509-0400</orcidid><orcidid>https://orcid.org/0000-0003-0829-2143</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cells (Basel, Switzerland), 2024-01, Vol.13 (2), p.177 |
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| subjects | Anxiety Bacteria Behavior Colitis, Ulcerative Communication Comorbidity Complications and side effects Crohn's disease Cytokines Gastrointestinal tract gut microbiota gut–brain axis Humans IBD Immune response Immune system Inflammation Inflammatory bowel disease Inflammatory Bowel Diseases Innate immunity Intestine Kinases Mental depression Mental disorders Mental illness Metabolites Microbiota Microglia Neurogenesis neuroinflammation Pathogenesis Permeability Phagocytes Physiology psychiatric disorders Psychological aspects Quality of life Risk factors Tumor necrosis factor-TNF Ulcerative colitis |
| title | Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling |
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