Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

• Published in: Journal of basic & applied zoology 2018-01, Vol.79 (1), p.1-13, Article 3
• Main Authors: Mohammed, Hend A., Okail, Hanan A., Ibrahim, Mona A., Emam, Nahed M.
• Format: Article
• Language: English
• Subjects: Angiotensin; Angiotensin II; Antioxidants; Biomedical and Life Sciences; Body weight; Comparative Anatomy and Embryology; Creatinine; Diabetes; Diabetes mellitus; Dietary supplements; Fetuses; Gestation; Hyperglycemia; Immunoreactivity; Interstitial cells; Kidney function; Kidneys; Leaves; Life Sciences; Olive (Olea europaea); Oral administration; Placenta; Plant extracts; Pregnancy; Renal tubules; Rodents; Streptozocin; Urea; Zoology
• ISSN: 2090-990X; 2090-990X
• DOI: 10.1186/s41936-018-0024-8

Background Phytotherapeutic treatment is used in the treatment of diabetes and its complications. The current study aims to evaluate the significant effect of supplementation of aqueous olive leaf extract (OLE) ( Olea europaea ) in the kidney of diabetic pregnant mice and their fetuses. Forty pregnant mice were divided into four groups contained 10 mice each after mating. The first group was the control (G1). The second group (GII) was intraperitoneally injected by a single dose of (240 mg/kg body weight) of streptozotocin (STZ). The third group (GIII) was administrated with a daily oral dose of extract of olive leaf extract (100 mg/kg) from days 1 to 18 of gestation. The fourth group (GIV) was injected intraperitoneally by a single dose of (240 mg/kg body weight) of STZ and post-treatment with oral dose of extract of olive leaves from days 1 to day 18 of gestation. Results Both mothers and their fetuses of STZ-induced diabetic group showed a decrease in weight compared to control and diabetic group supplemented OLE extract. According to the biochemical and histopathological observations, the STZ-induced diabetic group showed a significant ( P