Single cells and transposable element heterogeneity in stem cells and development

Recent innovations in single cell sequencing-based technologies are shining a light on the heterogeneity of cellular populations in unprecedented detail. However, several cellular aspects are currently underutilized in single cell studies. One aspect is the expression and activity of transposable el...

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Published in:Cell regeneration 2021-07, Vol.10 (1), p.1-23, Article 23
Main Author: Hutchins, Andrew P.
Format: Article
Language:English
Subjects:
Binding sites
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cell division
Chromatin
DNA methylation
Epigenetics
Gene expression
Genetic engineering
Genomes
Life Sciences
Nucleotide sequence
Regenerative medicine
Research Highlight
Stem Cells
Studying Stem Cell and Developmental Biology with Single Cell Technologies
Transcription factors
Transcriptomes
Transposition
Transposons
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container_title Cell regeneration
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creator Hutchins, Andrew P.
description Recent innovations in single cell sequencing-based technologies are shining a light on the heterogeneity of cellular populations in unprecedented detail. However, several cellular aspects are currently underutilized in single cell studies. One aspect is the expression and activity of transposable elements (TEs). TEs are selfish sequences of DNA that can replicate, and have been wildly successful in colonizing genomes. However, most TEs are mutated, fragmentary and incapable of transposition, yet they are actively bound by multiple transcription factors, host complex patterns of chromatin modifications, and are expressed in mRNAs as part of the transcriptome in both normal and diseased states. The contribution of TEs to development and cellular function remains unclear, and the routine inclusion of TEs in single cell sequencing analyses will potentially lead to insight into stem cells, development and human disease.
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subjects Binding sites
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cell division
Chromatin
DNA methylation
Epigenetics
Gene expression
Genetic engineering
Genomes
Life Sciences
Nucleotide sequence
Regenerative medicine
Research Highlight
Stem Cells
Studying Stem Cell and Developmental Biology with Single Cell Technologies
Transcription factors
Transcriptomes
Transposition
Transposons
title Single cells and transposable element heterogeneity in stem cells and development
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