The effects of combined spinal-epidural analgesia and epidural anesthesia on maternal intrapartum temperature: a randomized controlled trial

Background Labor epidural analgesia has been suggested to be associated with intrapartum fever. We designed this study to investigate the effects of epidural analgesia and combined spinal-epidural analgesia on maternal intrapartum temperature. Methods Four hundred healthy nullipara patients were ran...

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Bibliographic Details
Published in:BMC anesthesiology 2022-11, Vol.22 (1), p.1-352, Article 352
Main Authors: Yao, Zhiping, Zhou, Jingxin, Li, Shuying, Zhou, Wenqin
Format: Article
Language:English
Subjects:
Analgesia
Analysis
Anesthesia
Antibiotics
Bupivacaine
Catheters
Childbirth & labor
Combined spinal-epidural analgesia
Epidural
Epidural anesthesia
Fever
Gestational age
Maternal intrapartum temperature
Neonates
Obstetrics
Pain perception
Pregnancy complications
Sufentanil
Variance analysis
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Summary:Background Labor epidural analgesia has been suggested to be associated with intrapartum fever. We designed this study to investigate the effects of epidural analgesia and combined spinal-epidural analgesia on maternal intrapartum temperature. Methods Four hundred healthy nullipara patients were randomly assigned to receive either epidural analgesia (EA group) or combined spinal-epidural analgesia (CSEA group). Maternal temperature was measured hourly after analgesia administration. The primary outcome was the incidence of maternal fever, and the secondary outcomes were the duration of analgesia, analgesia to full cervical dilation and analgesia to delivery. Neonatal outcomes and other basic labor events were also recorded. Results Maternal temperature gradually increased with time in both analgesia groups during labor. However, the CSEA group had a lower incidence of maternal fever, and a lower mean maternal temperature at 5 h, 6 h, and 9 h after analgesia. In addtion, the CSEA group also had a shorter time of analgesia duration, analgesia to full cervical dilation, analgesia to delivery, and less dose of epidural local anesthetic than the EA group. Conclusion Our findings suggest that combined spinal-epidural analgesia is associated with a lower risk of intrapartum fever than epidural analgesia. Trial registration ChiCTR1900026606. Registered on 16/10/2019. Keywords: Combined spinal-epidural analgesia, Epidural anesthesia, Maternal intrapartum temperature, Fever
ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-022-01898-w