Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea

Cancers are the leading cause of death among people living with HIV/AIDS (PLWHA); however, nationwide studies on cancer incidence are limited. We aimed to determine the trends in the incidence rates of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) among Korean PLWHA. Data from t...

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Published in:Scientific reports 2022-06, Vol.12 (1), p.9974-9974, Article 9974
Main Authors: Lee, Soon Ok, Lee, Jeong Eun, Lee, Shinwon, Lee, Sun Hee, Kang, Jin Suk, Son, Hyunjin, Lee, Hyungi, Kim, Jinmi
Format: Article
Language:English
Subjects:
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Acquired immune deficiency syndrome
AIDS
Antiretroviral agents
Antiretroviral therapy
Cancer
Cervical cancer
Cervix
HIV
Human immunodeficiency virus
Humanities and Social Sciences
Kaposi's sarcoma
Liver cancer
Lung cancer
Lymphoma
multidisciplinary
Non-Hodgkin's lymphoma
Oropharyngeal cancer
Patients
Sarcoma
Science
Science (multidisciplinary)
Sexually transmitted diseases
STD
Survival
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Summary:Cancers are the leading cause of death among people living with HIV/AIDS (PLWHA); however, nationwide studies on cancer incidence are limited. We aimed to determine the trends in the incidence rates of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) among Korean PLWHA. Data from the National Health Insurance Sharing Service from 2004 to 2017 were collected. Age- and sex-adjusted standardized incidence ratios (SIRs) for various cancer types relative to the general population were calculated. Of the 11,737 PLWHA followed-up for 65,052 person-years (PYs), 445 (ADCs, 130 and NADCs, 298) developed cancer. The incidence rate of ADCs decreased, whereas that of NADCs remained unchanged. PLWHA were at an increased risk of ADCs (SIR: 12.6, 95% CI: 10.6–15.0), including Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer, and some NADCs, including anal cancer, lung cancer, liver cancer, and oropharyngeal cancer. Of the 396 patients who received antiretroviral therapy (ART), 215 with optimal adherence had lower incidence rates for ADCs and NADCs than those with non-optimal adherence. The 5-year survival rate of PLWHA with NADCs was 57.8%. Close surveillance and routine screening of cancers and improvement in ART adherence are required to improve the clinical outcomes of PLWHA.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-14170-5