Colorimetric Chemosensor Based on Fe3O4 Magnetic Molecularly Imprinted Nanoparticles for Highly Selective and Sensitive Detection of Norfloxacin in Milk

Long-term use of norfloxacin (NOR) will cause NOR residues in foods and harm human bodies. The determination of NOR residues is important for guaranteeing food safety. In this study, a simple, selective, and label-free colorimetric chemosensor for in situ NOR detection was developed based on Fe3O4 m...

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Bibliographic Details
Published in:Foods 2023-01, Vol.12 (2), p.285
Main Authors: Li, Maiquan, Luo, Lingli, Li, Jiayin, Xiong, Yingzi, Wang, Ling, Liu, Xia
Format: Article
Language:English
Subjects:
Bisphenol A
Catalytic activity
Catalytic oxidation
Chemical sensors
Chemoreceptors
colorimetric chemosensor
Colorimetry
Drug resistance
Enzymes
Experiments
Fe3O4 MMIP NPs
Food safety
Food science
Hydrogen peroxide
Iron oxides
Medical research
Milk
Nanoparticles
Norfloxacin
norfloxacin detection
Peroxidase
peroxidase-like catalytic activity
Reproducibility
Residues
Selective adsorption
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Summary:Long-term use of norfloxacin (NOR) will cause NOR residues in foods and harm human bodies. The determination of NOR residues is important for guaranteeing food safety. In this study, a simple, selective, and label-free colorimetric chemosensor for in situ NOR detection was developed based on Fe3O4 magnetic molecularly imprinted nanoparticles (Fe3O4 MMIP NPs). The Fe3O4 MMIP NPs showed good peroxidase-like catalytic activity to 3,3′,5,5′-tetramethylbenzidine (TMB) and selective adsorption ability to NOR. The colorimetric chemosensor was constructed based on the Fe3O4 MMIP NPs-H2O2-TMB reaction system. The absorbance differences were proportional to the concentrations of NOR in the range of 10–300 ng/mL with a limit of detection at 9 ng/mL. The colorimetric chemosensor was successfully applied to detect NOR residue in milk. The recovery range was 78.2–95.81%, with a relative standard deviation of 2.1–9.88%. Together, the proposed colorimetric chemosensor provides a reliable strategy for the detection of NOR residues in foods.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods12020285