A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review

A well-documented method and experimental design are essential to ensure the reproducibility and reliability in animal research. Experimental studies using exercise programs in animal models have experienced an exponential increase in the last decades. Complete reporting of forced wheel and treadmil...

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Published in:Frontiers in endocrinology (Lausanne) 2021-05, Vol.12, p.638261-638261
Main Authors: Garrigos, Daniel, Martínez-Morga, Marta, Toval, Angel, Kutsenko, Yevheniy, Barreda, Alberto, Do Couto, Bruno Ribeiro, Navarro-Mateu, Fernando, Ferran, José Luis
Format: Article
Language:English
Subjects:
Animal Experimentation - standards
animal research
Animals
Disease Models, Animal
Endocrinology
Exercise
Exercise Test
Female
forced exercise
forced wheel
Humans
Humidity
Male
Mice
Physical Conditioning, Animal
Rats
Reproducibility of Results
research guidelines
Risk
rodent exercise
Temperature
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Summary:A well-documented method and experimental design are essential to ensure the reproducibility and reliability in animal research. Experimental studies using exercise programs in animal models have experienced an exponential increase in the last decades. Complete reporting of forced wheel and treadmill exercise protocols would help to ensure the reproducibility of training programs. However, forced exercise programs are characterized by a poorly detailed methodology. Also, current guidelines do not cover the minimum data that must be included in published works to reproduce training programs. For this reason, we have carried out a systematic review to determine the reproducibility of training programs and experimental designs of published research in rodents using a forced wheel system. Having determined that most of the studies were not detailed enough to be reproducible, we have suggested guidelines for animal research using FORCED exercise wheels, which could also be applicable to any form of forced exercise.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.638261