Effects of Ferroptosis on Male Reproduction

Ferroptosis is a relatively novel form of regulated cell death that was discovered in 2012. With the increasing research related to the mechanisms of ferroptosis, previous studies have demonstrated that the inactive of the intracellular antioxidant system and iron overload can result in the accumula...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (13), p.7139
Main Authors: Liu, Yang, Cao, Xuanhong, He, Chen, Guo, Xinrui, Cai, Hui, Aierken, Aili, Hua, Jinlian, Peng, Sha
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Autophagy
Cell death
Decomposition
Deoxyribonucleic acid
DNA
DNA damage
Fatty acids
Ferroptosis
Free radicals
Homeostasis
Iron
iron metabolism
Lipid peroxidation
Lipids
male reproductive disorders
Male reproductive system
Metabolic networks
Metabolism
Overloading
Oxidative stress
Physiology
Reactive oxygen species
Reproductive pathology
Review
Vitamins
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Summary:Ferroptosis is a relatively novel form of regulated cell death that was discovered in 2012. With the increasing research related to the mechanisms of ferroptosis, previous studies have demonstrated that the inactive of the intracellular antioxidant system and iron overload can result in the accumulation of reactive oxygen species (ROS), which can ultimately cause lipid peroxidation in the various cell types of the body. ROS accumulation can cause sperm damage by attacking the plasma membrane and damaging DNA. Acute ferroptosis causes oxidative damage to sperm DNA and testicular oxidative stress, thereby causing male reproductive dysfunction. This review aims to discuss the metabolic network of ferroptosis, summarize and analyze the relationship between male reproductive diseases caused by iron overload as well as lipid peroxidation, and provide a novel direction for the research and prevention of various male reproductive diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137139