Role of cholesterol in regulating apolipoprotein B secretion by the liver

The review examines the evidence that the supply of cholesterol available for incorporation into nascent lipoprotein particles exerts a regulatory influence on apolipoprotein (apo) B secretion by the liver. Support for this hypothesis comes both from in vitro experiments and from recent observations...

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Bibliographic Details
Published in:Journal of lipid research 1996-03, Vol.37 (3), p.439-447
Main Authors: Thompson, G R, Naoumova, R P, Watts, G F
Format: Article
Language:English
Subjects:
Acyl Coenzyme A - metabolism
Animals
Apolipoproteins B - metabolism
Bile - metabolism
Cholesterol - biosynthesis
Cholesterol - physiology
Cholesterol Esters - metabolism
Humans
Hyperlipoproteinemia Type II - metabolism
Lipid Metabolism
Lipoproteins - biosynthesis
Lipoproteins - metabolism
Lipoproteins, VLDL - metabolism
Liver - metabolism
Mevalonic Acid - blood
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Summary:The review examines the evidence that the supply of cholesterol available for incorporation into nascent lipoprotein particles exerts a regulatory influence on apolipoprotein (apo) B secretion by the liver. Support for this hypothesis comes both from in vitro experiments and from recent observations in normal subjects and patients with dyslipidemia associated with familial hypercholesterolemia, obesity, noninsulin dependent diabetes mellitus, growth hormone deficiency and cholesteryl ester storage disease. The findings do not negate a role for triglyceride synthesis in determining apoB secretion in very low density lipoprotein, but the inhibitory effects on the latter process of pharmacological blockade of cholesterol synthesis or esterification suggest that it is conditional upon an adequate supply of cholesteryl ester.
ISSN:0022-2275
DOI:10.1016/s0022-2275(20)37589-1