Epidemiology and Long-Term Outcomes in Thoracic Transplantation

Over the past five decades, outcomes for lung transplantation have significantly improved in the early post-operative period, such that lung transplant is now the gold standard treatment for end-stage respiratory disease. The major limitation that impacts lung transplant survival rates is the develo...

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Bibliographic Details
Published in:Journal of cardiovascular development and disease 2023-09, Vol.10 (9), p.397
Main Authors: Abraham, Abey S, Singh, Manila, Abraham, Matthew S, Ahuja, Sanchit
Format: Article
Language:English
Subjects:
Care and treatment
chronic lung allograft dysfunction
Chronic obstructive pulmonary disease
Epidemiology
Imipenem
lung disease
Lung diseases
lung transplant survival
lung transplantation
Lung transplants
Medical prognosis
Organ transplant recipients
Patient outcomes
Patients
Physiology
primary graft dysfunction
Pulmonary arteries
Pulmonary fibrosis
Review
Sutures
Transplantation of organs, tissues, etc
Veins & arteries
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Summary:Over the past five decades, outcomes for lung transplantation have significantly improved in the early post-operative period, such that lung transplant is now the gold standard treatment for end-stage respiratory disease. The major limitation that impacts lung transplant survival rates is the development of chronic lung allograft dysfunction (CLAD). CLAD affects around 50% of lung transplant recipients within five years of transplantation. We must also consider other factors impacting the survival rate such as the surgical technique (single versus double lung transplant), along with donor and recipient characteristics. The future is promising, with more research looking into ex vivo lung perfusion (EVLP) and bioengineered lungs, with the hope of increasing the donor pool and decreasing the risk of graft rejection.
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd10090397