Nerve conduction study of the association between glycemic variability and diabetes neuropathy

It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN). We investigated the association between glycemic variability and DPN with type 1 or 2 diabetes. Forty patients (23 males and 17 females; aged 34-79 years) un...

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Published in:Diabetology and metabolic syndrome 2018-09, Vol.10 (1), p.69-69, Article 69
Main Authors: Akaza, Miho, Akaza, Itaru, Kanouchi, Tadashi, Sasano, Tetsuo, Sumi, Yuki, Yokota, Takanori
Format: Article
Language:English
Subjects:
Action potential
Analysis
Angina pectoris
Blood glucose
Care and treatment
Cholesterol
Complications and side effects
Continuous glucose monitoring
Control
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes peripheral neuropathy
Diabetic neuropathy
Diabetic retinopathy
Glucose
Glucose monitoring
Glycemic variability
Hyperglycemia
Hypoglycemia
Insulin
Kinases
Microvasculature
Nerve conduction
Nerve conduction study
Oxidative stress
Peptides
Peripheral neuropathy
Quality of life
Risk factors
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Summary:It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN). We investigated the association between glycemic variability and DPN with type 1 or 2 diabetes. Forty patients (23 males and 17 females; aged 34-79 years) underwent continuous glucose monitoring (CGM) and a nerve conduction study (NCS). Glycemic variability was estimated by mean amplitude of glycemic excursions (MAGE) in CGM. DPN was quantitatively evaluated by NCS in the median, tibial, sural and medial plantar nerves. MAGE had a significantly positive correlation with disease duration and low-density lipoprotein cholesterol level (r = 0.462, p = 0.003; and r = 0.40, p = 0.011, respectively), and a significantly negative correlation with BMI and medial plantar compound nerve action potential amplitude (r = - 0.39, p = 0.012; and r = - 0.32, p = 0.042, respectively). Multivariate linear regression analysis with adjustment for clinical background showed that MAGE (β = - 0.49, p= 0.007) was independently associated with a higher risk of medial plantar neuropathy. Glycemic variability may be an independent risk factor for DPN.
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-018-0371-0