Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232–Carrying Klebsiella pneumoniae Sequence Type 15 Lineage

Prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has compromised antimicrobial efficacy against severe infections worldwide. To monitor global spread, we conducted a comprehensive genomic epidemiologic study comparing sequences from 21 blaOXA-232–carrying CRKP isolates from China with...

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Bibliographic Details
Published in:Emerging infectious diseases 2023-11, Vol.29 (11), p.2246-2256
Main Authors: Wu, Yuye, Jiang, Tian, He, Xianhong, Shao, Jiayu, Wu, Chenghao, Mao, Weifang, Jia, Huiqiong, He, Fang, Kong, Yingying, Wu, Jianyong, Sun, Qingyang, Long, Sun, Draz, Mohamed S, Xie, Xinyou, Zhang, Jun, Ruan, Zhi
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
antimicrobial resistance
Bacteria
blaOXA-232
carbapenem resistance
carbapenemases
Carrying
E coli
Enterobacterales
Epidemiology
Genes
Genomes
Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant
Infections
Klebsiella pneumoniae
Nosocomial infections
Phylogenetics
Plasmids
Sequence Type 15 Lineage
Virulence
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Summary:Prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has compromised antimicrobial efficacy against severe infections worldwide. To monitor global spread, we conducted a comprehensive genomic epidemiologic study comparing sequences from 21 blaOXA-232–carrying CRKP isolates from China with K. pneumoniae sequence type (ST) 15 strains from 68 countries available in GenBank. Phylogenetic and phylogeographic analyses revealed all blaOXA-232–carrying CRKP isolates belonged to ST15 lineage and exhibited multidrug resistance. Analysis grouped 330 global blaOXA-232–carrying ST15 CRKP strains into 5 clades, indicating clonal transmission with small genetic distances among multiple strains. The lineage originated in the United States, then spread to Europe, Asia, Oceania, and Africa. Most recent common ancestor was traced back to 2000; mutations averaged ≈1.7 per year per genome. Our research helps identify key forces driving global spread of blaOXA-232–carrying CRKP ST15 lineage and emphasizes the importance of ongoing surveillance of epidemic CRKP.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2911.230463