The effect of COVID-19 vaccination on symptomatic infection and related symptoms among preterm-born children aged 3–7 years in China

Vaccination plays a crucial role in preventing and controlling SARS-CoV-2 infections as well as their associated adverse outcomes. But there is a notable lack of research on the effectiveness of COVID-19 vaccination in children, particularly those young preterm-born children, who are more vulnerable...

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Bibliographic Details
Published in:Scientific reports 2024-10, Vol.14 (1), p.25384-10, Article 25384
Main Authors: Wang, Dan, Ning, Jia-Dong, Cao, Jingke, Liu, Changgen, Tang, Shanghong, Feng, Zhichun, Han, Tao, Li, Li, Li, Qiuping
Format: Article
Language:English
Subjects:
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692/700
Child
Child, Preschool
Children
China - epidemiology
Combined vaccines
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Entropy
Female
Fever
Humanities and Social Sciences
Humans
Immunization
Infant, Premature
Infections
Male
multidisciplinary
Pediatrics
Pharyngitis
Premature Birth - epidemiology
Premature Birth - etiology
Premature Birth - prevention & control
Preterm-born children
Regression analysis
Retrospective Studies
SARS-CoV-2 - immunology
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Symptomatic infection
Vaccination
Vaccines
Vaccines, Inactivated - administration & dosage
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Summary:Vaccination plays a crucial role in preventing and controlling SARS-CoV-2 infections as well as their associated adverse outcomes. But there is a notable lack of research on the effectiveness of COVID-19 vaccination in children, particularly those young preterm-born children, who are more vulnerable to severe outcomes from SARS-CoV-2 infection. We aimed to determine the effect of vaccination with inactivated vaccines BBIBP-CorV and CoronaVac on symptomatic COVID-19 infection and related symptoms in preterm-born children aged 3–7 years after relaxation of the COVID-19 prevention and control measures in December 2022 in China. We performed a retrospective cohort study involving 242 preterm-born children aged 3–7 years and the data were collected in March 2023. Logistic regression models and modified Poisson regression models combined with entropy balancing were used to explore the associations of vaccination against SARS-CoV-2 with symptomatic COVID-19, specific symptoms, and persistent symptoms one month after recovery from COVID-19. Of the 242 recruited preterm-born children, 156 (64.5%) were vaccinated with inactivated vaccines BBIBP‐CorV and CoronaVac. After entropy balancing, the covariates were balanced between the vaccinated and the unvaccinated groups, with standardized mean difference 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-76609-1