Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge

• Published in: Arquivos brasileiros de cardiologia 2019-01, Vol.112 (1), p.12-17
• Main Authors: Enhos, Asim, Cosansu, Kahraman, Huyut, Mustafa Ahmet, Turna, Fahrettin, Karacop, Erdem, Bakshaliyev, Nijad, Nadir, Aydin, Ozdemir, Ramazan, Uluganyan, Mahmut
• Format: Article
• Language: English
• Subjects: Adult; Atherosclerosis; Atherosclerosis - blood; Biomarkers/blood; Blood Cell Count; CARDIAC & CARDIOVASCULAR SYSTEMS; Case-Control Studies; Cholesterol, HDL/blood; Cholesterol, LDL - blood; Coronary Angiography; Female; Humans; Inflammation; Lipoproteins, HDL - blood; Male; Middle Aged; Monocytes; Monocytes/citology; Multivariate Analysis; Myocardial Bridging; Myocardial Bridging - blood; Myocardial Bridging - etiology; Original; Reference Values; Regression Analysis; Risk Factors; Sensitivity and Specificity; Statistics, Nonparametric
• ISSN: 0066-782X; 1678-4170; 1678-4170
• DOI: 10.5935/abc.20180253

Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. To evaluate the relationhip between MHR and the presence of MB. We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients' angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant. MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors. The present study revealed a significant correlation between MHR and MB.