Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon

ObjectiveTo characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud’s phenomenon (RP).MethodsConsecutive children and adults with RP and without previously known connective tissue disease (CTD) sys...

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Bibliographic Details
Published in:Rheumatic & musculoskeletal diseases open 2023-03, Vol.9 (1), p.e003077
Main Authors: Mueller, Markus, Gschwandtner, Michael E, Emminger, Wolfgang, Kiener, Hans, Schnaubelt, Sebastian, Giurgea, Georgiana-Aura, Ristl, Robin, Perkmann, Thomas, Koppensteiner, Renate, Schlager, Oliver
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Antibodies
Antibodies, Antinuclear
Autoantibodies
Autoimmune Diseases
Autoimmunity
Blood vessels
Capillaries
Cardiovascular Diseases
Child
Connective Tissue Diseases
Cross-Sectional Studies
Edema
Humans
Immunology
Laboratories
Middle Aged
Nails - blood supply
Raynaud Disease - diagnosis
Raynaud Disease - etiology
Serology
Software
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Summary:ObjectiveTo characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud’s phenomenon (RP).MethodsConsecutive children and adults with RP and without previously known connective tissue disease (CTD) systemically underwent nailfold capillaroscopy and laboratory tests for the presence of antinuclear antibodies (ANA). The prevalence of individual nailfold capillary aberrations and ANA was assessed, and the associations between individual nailfold capillary aberrations and ANA were analysed separately in children and adolescents.ResultsIn total, 113 children (median age 15 years) and 2858 adults (median age 48 years) with RP and without previously known CTD were assessed. At least one nailfold capillary aberration was detected in 72 (64%) of included children and in 2154 (75%) of included adults with RP (children vs adults p
ISSN:2056-5933
2056-5933
DOI:10.1136/rmdopen-2023-003077