Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon

ObjectiveTo characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud’s phenomenon (RP).MethodsConsecutive children and adults with RP and without previously known connective tissue disease (CTD) sys...

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Published in:Rheumatic & musculoskeletal diseases open 2023-03, Vol.9 (1), p.e003077
Main Authors: Mueller, Markus, Gschwandtner, Michael E, Emminger, Wolfgang, Kiener, Hans, Schnaubelt, Sebastian, Giurgea, Georgiana-Aura, Ristl, Robin, Perkmann, Thomas, Koppensteiner, Renate, Schlager, Oliver
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Antibodies
Antibodies, Antinuclear
Autoantibodies
Autoimmune Diseases
Autoimmunity
Blood vessels
Capillaries
Cardiovascular Diseases
Child
Connective Tissue Diseases
Cross-Sectional Studies
Edema
Humans
Immunology
Laboratories
Middle Aged
Nails - blood supply
Raynaud Disease - diagnosis
Raynaud Disease - etiology
Serology
Software
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container_title Rheumatic & musculoskeletal diseases open
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creator Mueller, Markus
Gschwandtner, Michael E
Emminger, Wolfgang
Kiener, Hans
Schnaubelt, Sebastian
Giurgea, Georgiana-Aura
Ristl, Robin
Perkmann, Thomas
Koppensteiner, Renate
Schlager, Oliver
description ObjectiveTo characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud’s phenomenon (RP).MethodsConsecutive children and adults with RP and without previously known connective tissue disease (CTD) systemically underwent nailfold capillaroscopy and laboratory tests for the presence of antinuclear antibodies (ANA). The prevalence of individual nailfold capillary aberrations and ANA was assessed, and the associations between individual nailfold capillary aberrations and ANA were analysed separately in children and adolescents.ResultsIn total, 113 children (median age 15 years) and 2858 adults (median age 48 years) with RP and without previously known CTD were assessed. At least one nailfold capillary aberration was detected in 72 (64%) of included children and in 2154 (75%) of included adults with RP (children vs adults p
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The prevalence of individual nailfold capillary aberrations and ANA was assessed, and the associations between individual nailfold capillary aberrations and ANA were analysed separately in children and adolescents.ResultsIn total, 113 children (median age 15 years) and 2858 adults (median age 48 years) with RP and without previously known CTD were assessed. At least one nailfold capillary aberration was detected in 72 (64%) of included children and in 2154 (75%) of included adults with RP (children vs adults p&lt;0.05). An ANA titre ≥1:80, ≥1:160 or≥1:320 was observed in 29%, 21% or 16% of included children, and in 37%, 27% or 24% of screened adults, respectively. While the occurrence of individual nailfold capillary aberrations was related to the presence of an ANA titre of ≥1:80 in adults (reduced capillary density, avascular fields, haemorrhages, oedema, ramifications, dilations and giant capillaries: each p&lt;0.001), no comparable association between nailfold capillary aberrations and ANA was observed in children with RP without previously known CTD.ConclusionIn contrast to adults, the association between nailfold capillary aberrations and ANA might be less pronounced in children. Further studies are warranted to validate these observations in children with RP.</description><identifier>ISSN: 2056-5933</identifier><identifier>EISSN: 2056-5933</identifier><identifier>DOI: 10.1136/rmdopen-2023-003077</identifier><identifier>PMID: 36972928</identifier><language>eng</language><publisher>England: EULAR</publisher><subject>Adolescent ; Adult ; Adults ; Antibodies ; Antibodies, Antinuclear ; Autoantibodies ; Autoimmune Diseases ; Autoimmunity ; Blood vessels ; Capillaries ; Cardiovascular Diseases ; Child ; Connective Tissue Diseases ; Cross-Sectional Studies ; Edema ; Humans ; Immunology ; Laboratories ; Middle Aged ; Nails - blood supply ; Raynaud Disease - diagnosis ; Raynaud Disease - etiology ; Serology ; Software</subject><ispartof>Rheumatic &amp; musculoskeletal diseases open, 2023-03, Vol.9 (1), p.e003077</ispartof><rights>Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2023 Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b490t-965cdc59dc430e50e598e103bbf8ee24aa5b426268d690a26e734ae93b21c96e3</cites><orcidid>0000-0002-7976-0285 ; 0000-0001-6934-5355</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2791317307/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2791317307?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774,55331,74875,77409,77435</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36972928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mueller, Markus</creatorcontrib><creatorcontrib>Gschwandtner, Michael E</creatorcontrib><creatorcontrib>Emminger, Wolfgang</creatorcontrib><creatorcontrib>Kiener, Hans</creatorcontrib><creatorcontrib>Schnaubelt, Sebastian</creatorcontrib><creatorcontrib>Giurgea, Georgiana-Aura</creatorcontrib><creatorcontrib>Ristl, Robin</creatorcontrib><creatorcontrib>Perkmann, Thomas</creatorcontrib><creatorcontrib>Koppensteiner, Renate</creatorcontrib><creatorcontrib>Schlager, Oliver</creatorcontrib><title>Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon</title><title>Rheumatic &amp; musculoskeletal diseases open</title><addtitle>RMD Open</addtitle><addtitle>RMD Open</addtitle><description>ObjectiveTo characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud’s phenomenon (RP).MethodsConsecutive children and adults with RP and without previously known connective tissue disease (CTD) systemically underwent nailfold capillaroscopy and laboratory tests for the presence of antinuclear antibodies (ANA). The prevalence of individual nailfold capillary aberrations and ANA was assessed, and the associations between individual nailfold capillary aberrations and ANA were analysed separately in children and adolescents.ResultsIn total, 113 children (median age 15 years) and 2858 adults (median age 48 years) with RP and without previously known CTD were assessed. At least one nailfold capillary aberration was detected in 72 (64%) of included children and in 2154 (75%) of included adults with RP (children vs adults p&lt;0.05). An ANA titre ≥1:80, ≥1:160 or≥1:320 was observed in 29%, 21% or 16% of included children, and in 37%, 27% or 24% of screened adults, respectively. While the occurrence of individual nailfold capillary aberrations was related to the presence of an ANA titre of ≥1:80 in adults (reduced capillary density, avascular fields, haemorrhages, oedema, ramifications, dilations and giant capillaries: each p&lt;0.001), no comparable association between nailfold capillary aberrations and ANA was observed in children with RP without previously known CTD.ConclusionIn contrast to adults, the association between nailfold capillary aberrations and ANA might be less pronounced in children. 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Gschwandtner, Michael E ; Emminger, Wolfgang ; Kiener, Hans ; Schnaubelt, Sebastian ; Giurgea, Georgiana-Aura ; Ristl, Robin ; Perkmann, Thomas ; Koppensteiner, Renate ; Schlager, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b490t-965cdc59dc430e50e598e103bbf8ee24aa5b426268d690a26e734ae93b21c96e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Antibodies</topic><topic>Antibodies, Antinuclear</topic><topic>Autoantibodies</topic><topic>Autoimmune Diseases</topic><topic>Autoimmunity</topic><topic>Blood vessels</topic><topic>Capillaries</topic><topic>Cardiovascular Diseases</topic><topic>Child</topic><topic>Connective Tissue Diseases</topic><topic>Cross-Sectional Studies</topic><topic>Edema</topic><topic>Humans</topic><topic>Immunology</topic><topic>Laboratories</topic><topic>Middle Aged</topic><topic>Nails - blood supply</topic><topic>Raynaud Disease - diagnosis</topic><topic>Raynaud Disease - etiology</topic><topic>Serology</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mueller, Markus</creatorcontrib><creatorcontrib>Gschwandtner, Michael E</creatorcontrib><creatorcontrib>Emminger, Wolfgang</creatorcontrib><creatorcontrib>Kiener, Hans</creatorcontrib><creatorcontrib>Schnaubelt, Sebastian</creatorcontrib><creatorcontrib>Giurgea, Georgiana-Aura</creatorcontrib><creatorcontrib>Ristl, Robin</creatorcontrib><creatorcontrib>Perkmann, Thomas</creatorcontrib><creatorcontrib>Koppensteiner, Renate</creatorcontrib><creatorcontrib>Schlager, Oliver</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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musculoskeletal diseases open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mueller, Markus</au><au>Gschwandtner, Michael E</au><au>Emminger, Wolfgang</au><au>Kiener, Hans</au><au>Schnaubelt, Sebastian</au><au>Giurgea, Georgiana-Aura</au><au>Ristl, Robin</au><au>Perkmann, Thomas</au><au>Koppensteiner, Renate</au><au>Schlager, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon</atitle><jtitle>Rheumatic &amp; musculoskeletal diseases open</jtitle><stitle>RMD Open</stitle><addtitle>RMD Open</addtitle><date>2023-03</date><risdate>2023</risdate><volume>9</volume><issue>1</issue><spage>e003077</spage><pages>e003077-</pages><issn>2056-5933</issn><eissn>2056-5933</eissn><abstract>ObjectiveTo characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud’s phenomenon (RP).MethodsConsecutive children and adults with RP and without previously known connective tissue disease (CTD) systemically underwent nailfold capillaroscopy and laboratory tests for the presence of antinuclear antibodies (ANA). The prevalence of individual nailfold capillary aberrations and ANA was assessed, and the associations between individual nailfold capillary aberrations and ANA were analysed separately in children and adolescents.ResultsIn total, 113 children (median age 15 years) and 2858 adults (median age 48 years) with RP and without previously known CTD were assessed. At least one nailfold capillary aberration was detected in 72 (64%) of included children and in 2154 (75%) of included adults with RP (children vs adults p&lt;0.05). An ANA titre ≥1:80, ≥1:160 or≥1:320 was observed in 29%, 21% or 16% of included children, and in 37%, 27% or 24% of screened adults, respectively. While the occurrence of individual nailfold capillary aberrations was related to the presence of an ANA titre of ≥1:80 in adults (reduced capillary density, avascular fields, haemorrhages, oedema, ramifications, dilations and giant capillaries: each p&lt;0.001), no comparable association between nailfold capillary aberrations and ANA was observed in children with RP without previously known CTD.ConclusionIn contrast to adults, the association between nailfold capillary aberrations and ANA might be less pronounced in children. Further studies are warranted to validate these observations in children with RP.</abstract><cop>England</cop><pub>EULAR</pub><pmid>36972928</pmid><doi>10.1136/rmdopen-2023-003077</doi><orcidid>https://orcid.org/0000-0002-7976-0285</orcidid><orcidid>https://orcid.org/0000-0001-6934-5355</orcidid><oa>free_for_read</oa></addata></record>
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source BMJ Open Access Journals; Publicly Available Content Database; PubMed Central
subjects Adolescent
Adult
Adults
Antibodies
Antibodies, Antinuclear
Autoantibodies
Autoimmune Diseases
Autoimmunity
Blood vessels
Capillaries
Cardiovascular Diseases
Child
Connective Tissue Diseases
Cross-Sectional Studies
Edema
Humans
Immunology
Laboratories
Middle Aged
Nails - blood supply
Raynaud Disease - diagnosis
Raynaud Disease - etiology
Serology
Software
title Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon
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