Pineapple Leaf Phenols Attenuate DSS-Induced Colitis in Mice and Inhibit Inflammatory Damage by Targeting the NF-κB Pathway

• Published in: Molecules (Basel, Switzerland) Switzerland), 2021-12, Vol.26 (24), p.7656
• Main Authors: Chen, Yang, Niu, Yaoyun, Hao, Wenhui, Zhang, Wanqiu, Lu, Jinghua, Zhou, Jin, Du, Lijun, Xie, Weidong
• Format: Article
• Language: English
• Subjects: Acids; Ananas - chemistry; Animals; Antibiotics; caffeic acids; Caffeic Acids - chemistry; Caffeic Acids - pharmacology; Cancer; Colitis; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colon; Coumaric Acids - chemistry; Coumaric Acids - pharmacology; Dextran Sulfate - toxicity; Disease; Drinking water; Etiology; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Inflammatory bowel disease; Inflammatory response; Laboratory animals; Leaves; Male; Mice; Microbiota; Neutrophils; NF-kappa B - metabolism; NF-κB protein; Oral administration; p-coumaric acids; Phenols; Phenols - chemistry; Phenols - pharmacology; pineapple leaf phenols; Pineapples; Plant Leaves - chemistry; Signal Transduction - drug effects; Wound healing
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26247656

Colitis is not fully curable, although currently, some treatment options are being adopted. In this study, we investigated the effects of pineapple leaf phenols (PLPs), natural phenol products from pineapple leaves, on DSS-induced colitis in mice. The results showed that PLPs dramatically decreased the inflammatory response by inhibiting NF-κB activation and the secretion of pro-inflammatory factors. Moreover, PLPs provided protection against DSS-induced acute colitis by maintaining epithelial integrity. Caffeic and P-coumaric acids had similar effects and could be the active components responsible for PLPs' effect on colitis. These results indicate that the oral administration of PLPs might be considered as a therapeutic strategy in the treatment of patients with colitis. However, further research on clinical applications and the exact effect of PLPs on colitis is required.