A distinctively expressed long noncoding RNA, RP11‐466I1.1, may serve as a prognostic biomarker in hepatocellular carcinoma

It is urgent to explore effective diagnostic and prognostic biomarkers for hepatocellular carcinoma (HCC). Now, both lncRNAs and lipid metabolism are involved in tumor pathogenesis. Long noncoding RNA, RP11‐466I1.1, could likely be linked to lipid metabolism according to our bioinformatics analysis,...

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Published in:Cancer medicine (Malden, MA) MA), 2018-07, Vol.7 (7), p.2960-2968
Main Authors: Zhang, Junyong, Zhang, Di, Zhao, Qi, Qi, Jianni, Li, Xiao, Qin, Chengyong
Format: Article
Language:English
Subjects:
Bioinformatics
Biomarkers
Clinical Cancer Research
diagnosis
Hepatocellular carcinoma
Lipid metabolism
Liver cancer
long noncoding RNAs
Metabolism
Original Research
Pathogenesis
prognosis
Ribonucleic acid
RNA
Tumors
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Summary:It is urgent to explore effective diagnostic and prognostic biomarkers for hepatocellular carcinoma (HCC). Now, both lncRNAs and lipid metabolism are involved in tumor pathogenesis. Long noncoding RNA, RP11‐466I1.1, could likely be linked to lipid metabolism according to our bioinformatics analysis, yet studies about RP11‐466I1.1 expression in tumors and its potential functions are still lacking. We aimed to explore the expression and correlations with clinical features of a long noncoding RNA, RP11‐466I1.1, and further analyze its diagnostic and prognostic values in hepatocellular carcinoma. Expression levels of RP11‐466I1.1 were detected by quantitative real‐time PCR (qRT‐PCR) in tissue and serum level, and expression differences were analyzed by independent 2‐tailed t tests. Clinical features were obtained, and their correlations with RP11‐466I1.1 were analyzed by chi‐squared test. Receiver operating characteristic (ROC) curve was performed to assess the diagnostic value. Kaplan‐Meier method and log‐rank test were used to evaluate the prognostic value of RP11‐466I1.1. Results showed that RP11‐466I1.1 was upregulated in HCC tissues (P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.1565