Hyperglycaemia in Pregnancy and Anthropometric Parameters in the Offspring at 10 Years: A Community-Based Retrospective Cohort Study in Sri Lanka

Background. Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimat...

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Bibliographic Details
Published in:Journal of obesity 2020, Vol.2020 (2020), p.1-11
Main Authors: Herath, Himali P., Wickremasinghe, Rajitha, Herath, R. P.
Format: Article
Language:English
Subjects:
Age
Analysis
Anthropometry
Births
Body measurements
Child
Child care
Child development
Cohort analysis
Cohort Studies
Data collection
Feasibility studies
Female
Gestational diabetes
Glucose
Hospitals
Humans
Hyperglycemia
Hypotheses
Male
Metabolism
Mothers
Obesity
Obesity in children
Overweight
Pediatric Obesity - epidemiology
Pediatric Obesity - etiology
Pregnancy
Pregnancy Complications
Pregnant women
Prenatal Care
Prenatal Exposure Delayed Effects
Public health
Retrospective Studies
Sri Lanka - epidemiology
Type 2 diabetes
Waist Circumference
Womens health
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Summary:Background. Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero. Objective. The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age. Methods. A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded. Results. 159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, p
ISSN:2090-0708
2090-0716
DOI:10.1155/2020/2735148