NF90 in posttranscriptional gene regulation and microRNA biogenesis

Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA...

Full description

Saved in:
Bibliographic Details
Published in:International Journal of Molecular Sciences 2013-08, Vol.14 (8), p.17111-17121
Main Authors: Masuda, Kiyoshi, Kuwano, Yuki, Nishida, Kensei, Rokutan, Kazuhito, Imoto, Issei
Format: Article
Language:English
Subjects:
Animals
double-stranded RNA binding proteins
Gene Expression Regulation, Neoplastic
Humans
microRNA biogenesis
MicroRNAs - biosynthesis
MicroRNAs - genetics
Neoplasms - genetics
Neoplasms - metabolism
NF90
Nuclear Factor 90 Proteins - physiology
posttranscriptional regulation
Protein Biosynthesis
Review
RNA Interference
RNA Stability
RNA, Messenger - genetics
RNA, Messenger - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms140817111