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NF90 in posttranscriptional gene regulation and microRNA biogenesis

Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA...

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Published in:	International Journal of Molecular Sciences 2013-08, Vol.14 (8), p.17111-17121
Main Authors:	Masuda, Kiyoshi, Kuwano, Yuki, Nishida, Kensei, Rokutan, Kazuhito, Imoto, Issei
Format:	Article
Language:	English
Subjects:	Animals double-stranded RNA binding proteins Gene Expression Regulation, Neoplastic Humans microRNA biogenesis MicroRNAs - biosynthesis MicroRNAs - genetics Neoplasms - genetics Neoplasms - metabolism NF90 Nuclear Factor 90 Proteins - physiology posttranscriptional regulation Protein Biosynthesis Review RNA Interference RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism
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creator	Masuda, Kiyoshi Kuwano, Yuki Nishida, Kensei Rokutan, Kazuhito Imoto, Issei
description	Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.
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subjects	Animals double-stranded RNA binding proteins Gene Expression Regulation, Neoplastic Humans microRNA biogenesis MicroRNAs - biosynthesis MicroRNAs - genetics Neoplasms - genetics Neoplasms - metabolism NF90 Nuclear Factor 90 Proteins - physiology posttranscriptional regulation Protein Biosynthesis Review RNA Interference RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism
title	NF90 in posttranscriptional gene regulation and microRNA biogenesis
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